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The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis.
Studies were performed to determine whether localized treatment of subcutaneously growing Lewis Lung Carcinoma (LLC) in C57BL/6 mice with porphyrin photodynamic therapy (PDT) affects the formation of distant metastases. Treatments consisted of a 10 mg kg-1 dose of dihematoporphyrin-ether (Photofrin...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1987
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001674/ https://www.ncbi.nlm.nih.gov/pubmed/2956984 |
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author | Gomer, C. J. Ferrario, A. Murphree, A. L. |
author_facet | Gomer, C. J. Ferrario, A. Murphree, A. L. |
author_sort | Gomer, C. J. |
collection | PubMed |
description | Studies were performed to determine whether localized treatment of subcutaneously growing Lewis Lung Carcinoma (LLC) in C57BL/6 mice with porphyrin photodynamic therapy (PDT) affects the formation of distant metastases. Treatments consisted of a 10 mg kg-1 dose of dihematoporphyrin-ether (Photofrin II) followed 24 h later by local tumour irradiation with 630 nm red light. Total doses of light ranged from 0-500 J cm-2 and the irradiance of delivered light was 150 mW cm-2. Primary LLC tumours were treated at a volume of 25-30 mm3, and lung metastases were determined 21 days following transplantation. Mice exposed to PDT treatment which produced either partial or complete local tumoricidal responses had significantly decreased numbers of metastatic lung colonies compared to controls. In addition, PDT treated mice had equal or less metastatic lung colonies than comparable mice treated with local surgical excision of the primary LLC lesion. These results indicate that local PDT does not enhance metastatic spread of LLC following either curative or noncurative treatments. |
format | Text |
id | pubmed-2001674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1987 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20016742009-09-10 The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. Gomer, C. J. Ferrario, A. Murphree, A. L. Br J Cancer Research Article Studies were performed to determine whether localized treatment of subcutaneously growing Lewis Lung Carcinoma (LLC) in C57BL/6 mice with porphyrin photodynamic therapy (PDT) affects the formation of distant metastases. Treatments consisted of a 10 mg kg-1 dose of dihematoporphyrin-ether (Photofrin II) followed 24 h later by local tumour irradiation with 630 nm red light. Total doses of light ranged from 0-500 J cm-2 and the irradiance of delivered light was 150 mW cm-2. Primary LLC tumours were treated at a volume of 25-30 mm3, and lung metastases were determined 21 days following transplantation. Mice exposed to PDT treatment which produced either partial or complete local tumoricidal responses had significantly decreased numbers of metastatic lung colonies compared to controls. In addition, PDT treated mice had equal or less metastatic lung colonies than comparable mice treated with local surgical excision of the primary LLC lesion. These results indicate that local PDT does not enhance metastatic spread of LLC following either curative or noncurative treatments. Nature Publishing Group 1987-07 /pmc/articles/PMC2001674/ /pubmed/2956984 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Gomer, C. J. Ferrario, A. Murphree, A. L. The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. |
title | The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. |
title_full | The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. |
title_fullStr | The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. |
title_full_unstemmed | The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. |
title_short | The effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. |
title_sort | effect of localized porphyrin photodynamic therapy on the induction of tumour metastasis. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001674/ https://www.ncbi.nlm.nih.gov/pubmed/2956984 |
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