Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.

It is not yet clear whether some polymorphic variants of the Ha-ras-1 gene confer genetic predisposition to cancer. However, recent data on myelodysplasia and lung cancer are controversial. To clarify this point, 62 colorectal adenocarcinoma patients were examined for the Ha-ras-1 gene restriction f...

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Autores principales: Ceccherini-Nelli, L., De Re, V., Viel, A., Molaro, G., Zilli, L., Clemente, C., Boiocchi, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001679/
https://www.ncbi.nlm.nih.gov/pubmed/2887194
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author Ceccherini-Nelli, L.
De Re, V.
Viel, A.
Molaro, G.
Zilli, L.
Clemente, C.
Boiocchi, M.
author_facet Ceccherini-Nelli, L.
De Re, V.
Viel, A.
Molaro, G.
Zilli, L.
Clemente, C.
Boiocchi, M.
author_sort Ceccherini-Nelli, L.
collection PubMed
description It is not yet clear whether some polymorphic variants of the Ha-ras-1 gene confer genetic predisposition to cancer. However, recent data on myelodysplasia and lung cancer are controversial. To clarify this point, 62 colorectal adenocarcinoma patients were examined for the Ha-ras-1 gene restriction fragment length polymorphism and results were compared with those of 108 healthy blood donors. No Ha-ras-1 polymorphic variants specifically associated with the cancer patients were detected. However, a specific genotype was significantly more frequent in the healthy donors than in the cancer patients (16% versus 5%), suggesting an interaction between the two alleles of the gene. IMAGES:
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spelling pubmed-20016792009-09-10 Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma. Ceccherini-Nelli, L. De Re, V. Viel, A. Molaro, G. Zilli, L. Clemente, C. Boiocchi, M. Br J Cancer Research Article It is not yet clear whether some polymorphic variants of the Ha-ras-1 gene confer genetic predisposition to cancer. However, recent data on myelodysplasia and lung cancer are controversial. To clarify this point, 62 colorectal adenocarcinoma patients were examined for the Ha-ras-1 gene restriction fragment length polymorphism and results were compared with those of 108 healthy blood donors. No Ha-ras-1 polymorphic variants specifically associated with the cancer patients were detected. However, a specific genotype was significantly more frequent in the healthy donors than in the cancer patients (16% versus 5%), suggesting an interaction between the two alleles of the gene. IMAGES: Nature Publishing Group 1987-07 /pmc/articles/PMC2001679/ /pubmed/2887194 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ceccherini-Nelli, L.
De Re, V.
Viel, A.
Molaro, G.
Zilli, L.
Clemente, C.
Boiocchi, M.
Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
title Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
title_full Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
title_fullStr Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
title_full_unstemmed Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
title_short Ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
title_sort ha-ras-1 restriction fragment length polymorphism and susceptibility to colon adenocarcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001679/
https://www.ncbi.nlm.nih.gov/pubmed/2887194
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