Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.

The effect of sodium butyrate on mouse and human melanoma cell lines was evaluated. Sodium butyrate (0.1-2mM) is shown to reduce the clonogenic potential of several melanoma cell lines. The antiproliferative effect of sodium butyrate is accompanied by a marked increase in the activity of the plasma-...

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Autores principales: Nordenberg, J., Wasserman, L., Peled, A., Malik, Z., Stenzel, K. H., Novogrodsky, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001723/
https://www.ncbi.nlm.nih.gov/pubmed/2886147
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author Nordenberg, J.
Wasserman, L.
Peled, A.
Malik, Z.
Stenzel, K. H.
Novogrodsky, A.
author_facet Nordenberg, J.
Wasserman, L.
Peled, A.
Malik, Z.
Stenzel, K. H.
Novogrodsky, A.
author_sort Nordenberg, J.
collection PubMed
description The effect of sodium butyrate on mouse and human melanoma cell lines was evaluated. Sodium butyrate (0.1-2mM) is shown to reduce the clonogenic potential of several melanoma cell lines. The antiproliferative effect of sodium butyrate is accompanied by a marked increase in the activity of the plasma-membrane bound enzyme gamma-glutamyl transpeptidase. Sodium butyrate treated cells acquire a well developed rough endoplasmic reticulum and accumulate fat droplets. The development of the endoplasmic reticulum is associated with a marked increase in the activity of the enzyme marker NADPH cytochrome c reductase. It is suggested that the phenotypic alterations induced by sodium butyrate may serve as markers for the action of this agent on melanoma cells and other tumours. IMAGES:
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spelling pubmed-20017232009-09-10 Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells. Nordenberg, J. Wasserman, L. Peled, A. Malik, Z. Stenzel, K. H. Novogrodsky, A. Br J Cancer Research Article The effect of sodium butyrate on mouse and human melanoma cell lines was evaluated. Sodium butyrate (0.1-2mM) is shown to reduce the clonogenic potential of several melanoma cell lines. The antiproliferative effect of sodium butyrate is accompanied by a marked increase in the activity of the plasma-membrane bound enzyme gamma-glutamyl transpeptidase. Sodium butyrate treated cells acquire a well developed rough endoplasmic reticulum and accumulate fat droplets. The development of the endoplasmic reticulum is associated with a marked increase in the activity of the enzyme marker NADPH cytochrome c reductase. It is suggested that the phenotypic alterations induced by sodium butyrate may serve as markers for the action of this agent on melanoma cells and other tumours. IMAGES: Nature Publishing Group 1987-05 /pmc/articles/PMC2001723/ /pubmed/2886147 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Nordenberg, J.
Wasserman, L.
Peled, A.
Malik, Z.
Stenzel, K. H.
Novogrodsky, A.
Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.
title Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.
title_full Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.
title_fullStr Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.
title_full_unstemmed Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.
title_short Biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.
title_sort biochemical and ultrastructural alterations accompany the anti-proliferative effect of butyrate on melanoma cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001723/
https://www.ncbi.nlm.nih.gov/pubmed/2886147
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