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The effects of whole body hyperthermia on the pharmacokinetics and toxicity of the basic 2-nitroimidazole radiosensitizer Ro 03-8799 in mice.

We have investigated the effects of 50 min whole-body hyperthermia (WBH; 15 min equilibration followed by 41 degrees C for 35 min) on the toxicity and pharmacokinetics of the radiosensitizer Ro 03-8799 in mice. WBH markedly reduced Ro 03-8799 LD50/7d from 779 to 259 micrograms g-1 (P less than 0.001...

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Detalles Bibliográficos
Autores principales:	Walton, M. I., Bleehen, N. M., Workman, P.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1987
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001726/ https://www.ncbi.nlm.nih.gov/pubmed/3606940

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