Epidermal growth factor receptors in non-small cell lung cancer.

The epidermal growth factor receptor is homologous to the oncogene erb-beta and is the receptor for a class of tumour growth factors (TGF-alpha). The clinical correlations with its expression were studied in 77 non-small cell lung cancers (NSCLC). They were stained for epidermal growth factor recept...

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Autores principales: Veale, D., Ashcroft, T., Marsh, C., Gibson, G. J., Harris, A. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001730/
https://www.ncbi.nlm.nih.gov/pubmed/3038157
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author Veale, D.
Ashcroft, T.
Marsh, C.
Gibson, G. J.
Harris, A. L.
author_facet Veale, D.
Ashcroft, T.
Marsh, C.
Gibson, G. J.
Harris, A. L.
author_sort Veale, D.
collection PubMed
description The epidermal growth factor receptor is homologous to the oncogene erb-beta and is the receptor for a class of tumour growth factors (TGF-alpha). The clinical correlations with its expression were studied in 77 non-small cell lung cancers (NSCLC). They were stained for epidermal growth factor receptor (EGFr) by means of an indirect immunoperoxidase technique using a monoclonal antibody against the receptor. Normal lung tissue and normal bronchus were stained for comparison. Cancer tissue showed significantly increased staining compared to normal lung (P less than 0.05). Staining for EGFr in 40 squamous carcinomas was significantly stronger than in 37 specimens of other types of NSCLC (P less than 0.05), and staining in stage three NSCLC was stronger than in stage 1 and 2 (P less than 0.05). These results suggest that the presence of a high intensity of staining for EGF receptor is associated with spread of human non-small cell lung cancer and this receptor may be a suitable target for therapy. IMAGES:
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spelling pubmed-20017302009-09-10 Epidermal growth factor receptors in non-small cell lung cancer. Veale, D. Ashcroft, T. Marsh, C. Gibson, G. J. Harris, A. L. Br J Cancer Research Article The epidermal growth factor receptor is homologous to the oncogene erb-beta and is the receptor for a class of tumour growth factors (TGF-alpha). The clinical correlations with its expression were studied in 77 non-small cell lung cancers (NSCLC). They were stained for epidermal growth factor receptor (EGFr) by means of an indirect immunoperoxidase technique using a monoclonal antibody against the receptor. Normal lung tissue and normal bronchus were stained for comparison. Cancer tissue showed significantly increased staining compared to normal lung (P less than 0.05). Staining for EGFr in 40 squamous carcinomas was significantly stronger than in 37 specimens of other types of NSCLC (P less than 0.05), and staining in stage three NSCLC was stronger than in stage 1 and 2 (P less than 0.05). These results suggest that the presence of a high intensity of staining for EGF receptor is associated with spread of human non-small cell lung cancer and this receptor may be a suitable target for therapy. IMAGES: Nature Publishing Group 1987-05 /pmc/articles/PMC2001730/ /pubmed/3038157 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Veale, D.
Ashcroft, T.
Marsh, C.
Gibson, G. J.
Harris, A. L.
Epidermal growth factor receptors in non-small cell lung cancer.
title Epidermal growth factor receptors in non-small cell lung cancer.
title_full Epidermal growth factor receptors in non-small cell lung cancer.
title_fullStr Epidermal growth factor receptors in non-small cell lung cancer.
title_full_unstemmed Epidermal growth factor receptors in non-small cell lung cancer.
title_short Epidermal growth factor receptors in non-small cell lung cancer.
title_sort epidermal growth factor receptors in non-small cell lung cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001730/
https://www.ncbi.nlm.nih.gov/pubmed/3038157
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AT gibsongj epidermalgrowthfactorreceptorsinnonsmallcelllungcancer
AT harrisal epidermalgrowthfactorreceptorsinnonsmallcelllungcancer

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