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Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat.
Postoperative hyperplasia enhances experimental intestinal carcinogenesis, but the effects of nonsurgical adaptation are uncertain. The tropic and tumour-promoting potentials of moderate hypothermia were tested in two groups of male Sprague-Dawley rats housed at 10 degrees C for 30 weeks. One group...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1987
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001761/ https://www.ncbi.nlm.nih.gov/pubmed/3567060 |
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author | Rainey, J. B. Davies, P. W. Williamson, R. C. |
author_facet | Rainey, J. B. Davies, P. W. Williamson, R. C. |
author_sort | Rainey, J. B. |
collection | PubMed |
description | Postoperative hyperplasia enhances experimental intestinal carcinogenesis, but the effects of nonsurgical adaptation are uncertain. The tropic and tumour-promoting potentials of moderate hypothermia were tested in two groups of male Sprague-Dawley rats housed at 10 degrees C for 30 weeks. One group (n = 10) received a 6-week course of azoxymethane (total dose 90 mg kg-1). The second group (n = 7) acted as hypothermic controls. Another 2 groups maintained at 22 degrees C received azoxymethane (n = 15) or served as normothermic controls (n = 15). Overall food intake was 42% higher in the hypothermic groups, yet at sacrifice mean body weight was 13% lower (P less than 0.01). Hypothermia and azoxymethane combined to produce the following increases in crypt cell production rate (CCPR), as determined stathmokinetically: duodenum 170%, jejunum 172%, ileum 74%, proximal colon 227% (P = 0.05-0.01). Independently hypothermia had no effect, but azoxymethane produced 76-156% increases in CCPR throughout the large intestine. Although hypothermia did not affect overall tumour yield, the mean diameter of proximal colonic tumours was increased by 65% (P less than 0.05). In rats receiving azoxymethane, hypothermia stimulates cell proliferation in the small bowel as well as in the proximal colon, where it has a correspondingly mild cocarcinogenic effect. |
format | Text |
id | pubmed-2001761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1987 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20017612009-09-10 Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. Rainey, J. B. Davies, P. W. Williamson, R. C. Br J Cancer Research Article Postoperative hyperplasia enhances experimental intestinal carcinogenesis, but the effects of nonsurgical adaptation are uncertain. The tropic and tumour-promoting potentials of moderate hypothermia were tested in two groups of male Sprague-Dawley rats housed at 10 degrees C for 30 weeks. One group (n = 10) received a 6-week course of azoxymethane (total dose 90 mg kg-1). The second group (n = 7) acted as hypothermic controls. Another 2 groups maintained at 22 degrees C received azoxymethane (n = 15) or served as normothermic controls (n = 15). Overall food intake was 42% higher in the hypothermic groups, yet at sacrifice mean body weight was 13% lower (P less than 0.01). Hypothermia and azoxymethane combined to produce the following increases in crypt cell production rate (CCPR), as determined stathmokinetically: duodenum 170%, jejunum 172%, ileum 74%, proximal colon 227% (P = 0.05-0.01). Independently hypothermia had no effect, but azoxymethane produced 76-156% increases in CCPR throughout the large intestine. Although hypothermia did not affect overall tumour yield, the mean diameter of proximal colonic tumours was increased by 65% (P less than 0.05). In rats receiving azoxymethane, hypothermia stimulates cell proliferation in the small bowel as well as in the proximal colon, where it has a correspondingly mild cocarcinogenic effect. Nature Publishing Group 1987-03 /pmc/articles/PMC2001761/ /pubmed/3567060 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Rainey, J. B. Davies, P. W. Williamson, R. C. Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. |
title | Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. |
title_full | Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. |
title_fullStr | Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. |
title_full_unstemmed | Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. |
title_short | Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. |
title_sort | effect of hypothermia on intestinal adaptation and carcinogenesis in the rat. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001761/ https://www.ncbi.nlm.nih.gov/pubmed/3567060 |
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