Cargando…

Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.

Zn(II)-phthalocyanine (Zn-Pc) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally (0.5 mg kg-1) to BALB/c mice bearing a transplanted MS-2 fibrosarcoma. The drug is specifically transported by serum lipoproteins and cleared from the serum via...

Descripción completa

Detalles Bibliográficos
Autores principales: Reddi, E., Lo Castro, G., Biolo, R., Jori, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001878/
https://www.ncbi.nlm.nih.gov/pubmed/3426922
_version_ 1782135679065522176
author Reddi, E.
Lo Castro, G.
Biolo, R.
Jori, G.
author_facet Reddi, E.
Lo Castro, G.
Biolo, R.
Jori, G.
author_sort Reddi, E.
collection PubMed
description Zn(II)-phthalocyanine (Zn-Pc) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally (0.5 mg kg-1) to BALB/c mice bearing a transplanted MS-2 fibrosarcoma. The drug is specifically transported by serum lipoproteins and cleared from the serum via the bile-gut pathway in a biphasic process: approximately 60% of Zn-Pc is eliminated with a serum half-life of approximately 9 hours, while the remaining aliquot is eliminated at a very slow rate. Several normal tissues take up the drug within 3 hours after administration but release it almost completely after 24-48 hours. On the other hand, the tumour shows a maximum concentration of Zn-Pc (approximately 0.6 microgram g-1 of tissue) after 18-24 hours; at this time, the ratio between the Zn-Pc levels in the tumour and the muscle (which represents the surrounding normal tissue) is approximately 7.5. The results are discussed in terms of a possible use of Zn-Pc as a photosensitizer in the photodynamic therapy of tumours.
format Text
id pubmed-2001878
institution National Center for Biotechnology Information
language English
publishDate 1987
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20018782009-09-10 Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. Reddi, E. Lo Castro, G. Biolo, R. Jori, G. Br J Cancer Research Article Zn(II)-phthalocyanine (Zn-Pc) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally (0.5 mg kg-1) to BALB/c mice bearing a transplanted MS-2 fibrosarcoma. The drug is specifically transported by serum lipoproteins and cleared from the serum via the bile-gut pathway in a biphasic process: approximately 60% of Zn-Pc is eliminated with a serum half-life of approximately 9 hours, while the remaining aliquot is eliminated at a very slow rate. Several normal tissues take up the drug within 3 hours after administration but release it almost completely after 24-48 hours. On the other hand, the tumour shows a maximum concentration of Zn-Pc (approximately 0.6 microgram g-1 of tissue) after 18-24 hours; at this time, the ratio between the Zn-Pc levels in the tumour and the muscle (which represents the surrounding normal tissue) is approximately 7.5. The results are discussed in terms of a possible use of Zn-Pc as a photosensitizer in the photodynamic therapy of tumours. Nature Publishing Group 1987-11 /pmc/articles/PMC2001878/ /pubmed/3426922 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Reddi, E.
Lo Castro, G.
Biolo, R.
Jori, G.
Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
title Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
title_full Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
title_fullStr Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
title_full_unstemmed Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
title_short Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
title_sort pharmacokinetic studies with zinc(ii)-phthalocyanine in tumour-bearing mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001878/
https://www.ncbi.nlm.nih.gov/pubmed/3426922
work_keys_str_mv AT reddie pharmacokineticstudieswithzinciiphthalocyanineintumourbearingmice
AT locastrog pharmacokineticstudieswithzinciiphthalocyanineintumourbearingmice
AT biolor pharmacokineticstudieswithzinciiphthalocyanineintumourbearingmice
AT jorig pharmacokineticstudieswithzinciiphthalocyanineintumourbearingmice