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Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.
Zn(II)-phthalocyanine (Zn-Pc) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally (0.5 mg kg-1) to BALB/c mice bearing a transplanted MS-2 fibrosarcoma. The drug is specifically transported by serum lipoproteins and cleared from the serum via...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1987
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001878/ https://www.ncbi.nlm.nih.gov/pubmed/3426922 |
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author | Reddi, E. Lo Castro, G. Biolo, R. Jori, G. |
author_facet | Reddi, E. Lo Castro, G. Biolo, R. Jori, G. |
author_sort | Reddi, E. |
collection | PubMed |
description | Zn(II)-phthalocyanine (Zn-Pc) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally (0.5 mg kg-1) to BALB/c mice bearing a transplanted MS-2 fibrosarcoma. The drug is specifically transported by serum lipoproteins and cleared from the serum via the bile-gut pathway in a biphasic process: approximately 60% of Zn-Pc is eliminated with a serum half-life of approximately 9 hours, while the remaining aliquot is eliminated at a very slow rate. Several normal tissues take up the drug within 3 hours after administration but release it almost completely after 24-48 hours. On the other hand, the tumour shows a maximum concentration of Zn-Pc (approximately 0.6 microgram g-1 of tissue) after 18-24 hours; at this time, the ratio between the Zn-Pc levels in the tumour and the muscle (which represents the surrounding normal tissue) is approximately 7.5. The results are discussed in terms of a possible use of Zn-Pc as a photosensitizer in the photodynamic therapy of tumours. |
format | Text |
id | pubmed-2001878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1987 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20018782009-09-10 Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. Reddi, E. Lo Castro, G. Biolo, R. Jori, G. Br J Cancer Research Article Zn(II)-phthalocyanine (Zn-Pc) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally (0.5 mg kg-1) to BALB/c mice bearing a transplanted MS-2 fibrosarcoma. The drug is specifically transported by serum lipoproteins and cleared from the serum via the bile-gut pathway in a biphasic process: approximately 60% of Zn-Pc is eliminated with a serum half-life of approximately 9 hours, while the remaining aliquot is eliminated at a very slow rate. Several normal tissues take up the drug within 3 hours after administration but release it almost completely after 24-48 hours. On the other hand, the tumour shows a maximum concentration of Zn-Pc (approximately 0.6 microgram g-1 of tissue) after 18-24 hours; at this time, the ratio between the Zn-Pc levels in the tumour and the muscle (which represents the surrounding normal tissue) is approximately 7.5. The results are discussed in terms of a possible use of Zn-Pc as a photosensitizer in the photodynamic therapy of tumours. Nature Publishing Group 1987-11 /pmc/articles/PMC2001878/ /pubmed/3426922 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Reddi, E. Lo Castro, G. Biolo, R. Jori, G. Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. |
title | Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. |
title_full | Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. |
title_fullStr | Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. |
title_full_unstemmed | Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. |
title_short | Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice. |
title_sort | pharmacokinetic studies with zinc(ii)-phthalocyanine in tumour-bearing mice. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001878/ https://www.ncbi.nlm.nih.gov/pubmed/3426922 |
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