Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.

In order to determine the significance of local oestrogen biosynthesis within the breast, aromatase activity has been measured in adipose tissue from the breasts of women with either benign (n = 36) or malignant breast disease (n = 51). Particulate fractions from all samples possessed aromatase acti...

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Detalles Bibliográficos
Autores principales: O'Neill, J. S., Miller, W. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001885/
https://www.ncbi.nlm.nih.gov/pubmed/3426923
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author O'Neill, J. S.
Miller, W. R.
author_facet O'Neill, J. S.
Miller, W. R.
author_sort O'Neill, J. S.
collection PubMed
description In order to determine the significance of local oestrogen biosynthesis within the breast, aromatase activity has been measured in adipose tissue from the breasts of women with either benign (n = 36) or malignant breast disease (n = 51). Particulate fractions from all samples possessed aromatase activity, but levels in adipose tissue adjacent to malignant tumours were significantly higher than those in tissue close to benign breast lesions (P less than 0.0001). Elevated aromatase activity in adipose tissue from breast cancer patients may be of importance in view of the central role played by oestrogen in the natural history of breast cancer.
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spelling pubmed-20018852009-09-10 Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases. O'Neill, J. S. Miller, W. R. Br J Cancer Research Article In order to determine the significance of local oestrogen biosynthesis within the breast, aromatase activity has been measured in adipose tissue from the breasts of women with either benign (n = 36) or malignant breast disease (n = 51). Particulate fractions from all samples possessed aromatase activity, but levels in adipose tissue adjacent to malignant tumours were significantly higher than those in tissue close to benign breast lesions (P less than 0.0001). Elevated aromatase activity in adipose tissue from breast cancer patients may be of importance in view of the central role played by oestrogen in the natural history of breast cancer. Nature Publishing Group 1987-11 /pmc/articles/PMC2001885/ /pubmed/3426923 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
O'Neill, J. S.
Miller, W. R.
Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.
title Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.
title_full Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.
title_fullStr Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.
title_full_unstemmed Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.
title_short Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.
title_sort aromatase activity in breast adipose tissue from women with benign and malignant breast diseases.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001885/
https://www.ncbi.nlm.nih.gov/pubmed/3426923
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