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Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol.
Noradrenaline induced changes in the distribution of blood flow in implanted tumour and normal liver tissue was measured using blood flow tracer microspheres. The ratio of embolised microspheres in tumour compared to normal tissue was determined before and after the intravenous infusion of noradrena...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1987
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001891/ https://www.ncbi.nlm.nih.gov/pubmed/3426921 |
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author | Burton, M. A. Gray, B. N. |
author_facet | Burton, M. A. Gray, B. N. |
author_sort | Burton, M. A. |
collection | PubMed |
description | Noradrenaline induced changes in the distribution of blood flow in implanted tumour and normal liver tissue was measured using blood flow tracer microspheres. The ratio of embolised microspheres in tumour compared to normal tissue was determined before and after the intravenous infusion of noradrenaline, propranolol and a combination of the two drugs. The ratio was significantly decreased by noradrenaline alone but significantly increased when propranolol was added to the infusate. Propranolol had no effect on the ratio. The drug combination increased the tumour to normal ratio by approximately 69% and also doubled the proportion of microspheres entering the internal tumour circulation. This represents an enhanced relative blood supply to tumour and would provide a means of preferential carriage of blood borne cytotoxic agents to tumour tissue rather than normal tissue. |
format | Text |
id | pubmed-2001891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1987 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20018912009-09-10 Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. Burton, M. A. Gray, B. N. Br J Cancer Research Article Noradrenaline induced changes in the distribution of blood flow in implanted tumour and normal liver tissue was measured using blood flow tracer microspheres. The ratio of embolised microspheres in tumour compared to normal tissue was determined before and after the intravenous infusion of noradrenaline, propranolol and a combination of the two drugs. The ratio was significantly decreased by noradrenaline alone but significantly increased when propranolol was added to the infusate. Propranolol had no effect on the ratio. The drug combination increased the tumour to normal ratio by approximately 69% and also doubled the proportion of microspheres entering the internal tumour circulation. This represents an enhanced relative blood supply to tumour and would provide a means of preferential carriage of blood borne cytotoxic agents to tumour tissue rather than normal tissue. Nature Publishing Group 1987-11 /pmc/articles/PMC2001891/ /pubmed/3426921 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Burton, M. A. Gray, B. N. Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. |
title | Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. |
title_full | Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. |
title_fullStr | Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. |
title_full_unstemmed | Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. |
title_short | Redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. |
title_sort | redistribution of blood flow in experimental hepatic tumours with noradrenaline and propranolol. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001891/ https://www.ncbi.nlm.nih.gov/pubmed/3426921 |
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