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Collagen IV staining pattern in bladder carcinomas: relationship to prognosis.
A prospective study of type IV collagen in urothelial tissues was undertaken using an immunoperoxidase method on 125 ethanol fixed specimens. In normal and non cancerous urothelium, the basement membrane was continuously stained and the same pattern was seen in the 27 superficial carcinomas. In the...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1987
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002026/ https://www.ncbi.nlm.nih.gov/pubmed/3304387 |
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author | Daher, N. Abourachid, H. Bove, N. Petit, J. Burtin, P. |
author_facet | Daher, N. Abourachid, H. Bove, N. Petit, J. Burtin, P. |
author_sort | Daher, N. |
collection | PubMed |
description | A prospective study of type IV collagen in urothelial tissues was undertaken using an immunoperoxidase method on 125 ethanol fixed specimens. In normal and non cancerous urothelium, the basement membrane was continuously stained and the same pattern was seen in the 27 superficial carcinomas. In the 48 invasive bladder carcinomas, we observed two patterns of staining for collagen IV: in the first one, the staining line was conserved or partially fragmented (28 tumours), while in the second one the staining line was widely fragmented or absent in more than 5% of the tumour area (20 tumours). We found a highly significant statistical correlation between the pattern of staining and short term prognosis. Twenty-nine patients had an assessable follow-up of three years at least. All 16 patients with pattern I staining were alive at two years while only two out of 13 patients with pattern II staining survived two years (P less than 0.0001). At three years, all the patients with pattern II staining died while 11 patients with pattern I were still alive (P less than 0.001). These data provisionally indicate that the type IV collagen staining pattern may be of prognostic value in assessing the short term behaviour of invasive bladder carcinomas. It is thus logical to envisage that the treatment decisions may be influenced by the results of collagen IV staining. IMAGES: |
format | Text |
id | pubmed-2002026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1987 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20020262009-09-10 Collagen IV staining pattern in bladder carcinomas: relationship to prognosis. Daher, N. Abourachid, H. Bove, N. Petit, J. Burtin, P. Br J Cancer Research Article A prospective study of type IV collagen in urothelial tissues was undertaken using an immunoperoxidase method on 125 ethanol fixed specimens. In normal and non cancerous urothelium, the basement membrane was continuously stained and the same pattern was seen in the 27 superficial carcinomas. In the 48 invasive bladder carcinomas, we observed two patterns of staining for collagen IV: in the first one, the staining line was conserved or partially fragmented (28 tumours), while in the second one the staining line was widely fragmented or absent in more than 5% of the tumour area (20 tumours). We found a highly significant statistical correlation between the pattern of staining and short term prognosis. Twenty-nine patients had an assessable follow-up of three years at least. All 16 patients with pattern I staining were alive at two years while only two out of 13 patients with pattern II staining survived two years (P less than 0.0001). At three years, all the patients with pattern II staining died while 11 patients with pattern I were still alive (P less than 0.001). These data provisionally indicate that the type IV collagen staining pattern may be of prognostic value in assessing the short term behaviour of invasive bladder carcinomas. It is thus logical to envisage that the treatment decisions may be influenced by the results of collagen IV staining. IMAGES: Nature Publishing Group 1987-06 /pmc/articles/PMC2002026/ /pubmed/3304387 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Daher, N. Abourachid, H. Bove, N. Petit, J. Burtin, P. Collagen IV staining pattern in bladder carcinomas: relationship to prognosis. |
title | Collagen IV staining pattern in bladder carcinomas: relationship to prognosis. |
title_full | Collagen IV staining pattern in bladder carcinomas: relationship to prognosis. |
title_fullStr | Collagen IV staining pattern in bladder carcinomas: relationship to prognosis. |
title_full_unstemmed | Collagen IV staining pattern in bladder carcinomas: relationship to prognosis. |
title_short | Collagen IV staining pattern in bladder carcinomas: relationship to prognosis. |
title_sort | collagen iv staining pattern in bladder carcinomas: relationship to prognosis. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002026/ https://www.ncbi.nlm.nih.gov/pubmed/3304387 |
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