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In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.

Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladd...

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Detalles Bibliográficos
Autores principales: Iles, R. K., Oliver, R. T., Kitau, M., Walker, C., Chard, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002027/
https://www.ncbi.nlm.nih.gov/pubmed/2441730
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author Iles, R. K.
Oliver, R. T.
Kitau, M.
Walker, C.
Chard, T.
author_facet Iles, R. K.
Oliver, R. T.
Kitau, M.
Walker, C.
Chard, T.
author_sort Iles, R. K.
collection PubMed
description Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' bladder epithelia, the media contained hCG at levels ranging from between 34 and 3,600 IU l(-1). All other cell lines, including the 10 germ cell tumour lines gave negative results for hCG. These findings indicate that in vitro secretion of hCG is a common feature of normal and neoplastic bladder transitional epithelia, and support the hypothesis that parts of the genito-urinary epithelium have a potential for hCG production.
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spelling pubmed-20020272009-09-10 In vitro secretion of human chorionic gonadotrophin by bladder tumour cells. Iles, R. K. Oliver, R. T. Kitau, M. Walker, C. Chard, T. Br J Cancer Research Article Human chorionic gonadotrophin (hCG) and alphafetoprotein (AFP) were measured in culture media from a panel of 29 cell lines including 9 bladder carcinomas, 5 'normal' bladder epithelia, 10 germ cell tumours, and 5 miscellaneous tumours and 'normal' cell lines. In 7 of the 9 bladder carcinomas and 4 of the 5 'normal' bladder epithelia, the media contained hCG at levels ranging from between 34 and 3,600 IU l(-1). All other cell lines, including the 10 germ cell tumour lines gave negative results for hCG. These findings indicate that in vitro secretion of hCG is a common feature of normal and neoplastic bladder transitional epithelia, and support the hypothesis that parts of the genito-urinary epithelium have a potential for hCG production. Nature Publishing Group 1987-06 /pmc/articles/PMC2002027/ /pubmed/2441730 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Iles, R. K.
Oliver, R. T.
Kitau, M.
Walker, C.
Chard, T.
In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
title In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
title_full In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
title_fullStr In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
title_full_unstemmed In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
title_short In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
title_sort in vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002027/
https://www.ncbi.nlm.nih.gov/pubmed/2441730
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