Glutathione localisation in benign and malignant human breast lesions.

Reduced glutathione (GSH) has been demonstrated in benign and malignant human breast lesions using a newly developed histofluorescence technique. GSH was present in every lesion and in each case was localised to the epithelium. A semi-quantitative assessment revealed a moderate amount of GSH in norm...

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Autores principales: Murray, G. I., Burke, M. D., Ewen, S. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002032/
https://www.ncbi.nlm.nih.gov/pubmed/3620301
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author Murray, G. I.
Burke, M. D.
Ewen, S. W.
author_facet Murray, G. I.
Burke, M. D.
Ewen, S. W.
author_sort Murray, G. I.
collection PubMed
description Reduced glutathione (GSH) has been demonstrated in benign and malignant human breast lesions using a newly developed histofluorescence technique. GSH was present in every lesion and in each case was localised to the epithelium. A semi-quantitative assessment revealed a moderate amount of GSH in normal epithelium and fibroadenoma and a high level in apocrine metaplasia, epitheliosis and intraduct carcinoma. Invasive ductal carcinoma contained a variable amount of GSH. Correlation between fluorescence intensity and histological grade of ductal carcinomas was almost statistically significant but a relationship to oestrogen receptor status was not detected. The rapid assessment of GSH in breast cancer may aid in the selection of optimum chemotherapeutic regimens. IMAGES:
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spelling pubmed-20020322009-09-10 Glutathione localisation in benign and malignant human breast lesions. Murray, G. I. Burke, M. D. Ewen, S. W. Br J Cancer Research Article Reduced glutathione (GSH) has been demonstrated in benign and malignant human breast lesions using a newly developed histofluorescence technique. GSH was present in every lesion and in each case was localised to the epithelium. A semi-quantitative assessment revealed a moderate amount of GSH in normal epithelium and fibroadenoma and a high level in apocrine metaplasia, epitheliosis and intraduct carcinoma. Invasive ductal carcinoma contained a variable amount of GSH. Correlation between fluorescence intensity and histological grade of ductal carcinomas was almost statistically significant but a relationship to oestrogen receptor status was not detected. The rapid assessment of GSH in breast cancer may aid in the selection of optimum chemotherapeutic regimens. IMAGES: Nature Publishing Group 1987-06 /pmc/articles/PMC2002032/ /pubmed/3620301 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Murray, G. I.
Burke, M. D.
Ewen, S. W.
Glutathione localisation in benign and malignant human breast lesions.
title Glutathione localisation in benign and malignant human breast lesions.
title_full Glutathione localisation in benign and malignant human breast lesions.
title_fullStr Glutathione localisation in benign and malignant human breast lesions.
title_full_unstemmed Glutathione localisation in benign and malignant human breast lesions.
title_short Glutathione localisation in benign and malignant human breast lesions.
title_sort glutathione localisation in benign and malignant human breast lesions.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002032/
https://www.ncbi.nlm.nih.gov/pubmed/3620301
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