Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.

Vitamin A has been shown to potentiate the cytotoxic action of anticancer agents like vincristine (VCR) against drug resistant mouse P388 leukaemia cells. In vitro tests showed enhancement by retinyl acetate of cytocidal activities of VCR against drug-sensitive leukaemia (P388/S) and VCR-resistant l...

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Autores principales: Nogae, I., Kikuchi, J., Yamaguchi, T., Nakagawa, M., Shiraishi, N., Kuwano, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002191/
https://www.ncbi.nlm.nih.gov/pubmed/3663474
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author Nogae, I.
Kikuchi, J.
Yamaguchi, T.
Nakagawa, M.
Shiraishi, N.
Kuwano, M.
author_facet Nogae, I.
Kikuchi, J.
Yamaguchi, T.
Nakagawa, M.
Shiraishi, N.
Kuwano, M.
author_sort Nogae, I.
collection PubMed
description Vitamin A has been shown to potentiate the cytotoxic action of anticancer agents like vincristine (VCR) against drug resistant mouse P388 leukaemia cells. In vitro tests showed enhancement by retinyl acetate of cytocidal activities of VCR against drug-sensitive leukaemia (P388/S) and VCR-resistant leukaemia (P388/VCR) cells in culture; retinyl acetate rather specifically potentiated VCR against cultured P388/VCR cells than P388/S cells. The cellular accumulation of radioactive VCR was significantly enhanced in cultured P388/VCR cells when retinyl acetate was present. The efflux of VCR from drug-resistant cells was blocked by retinyl acetate. The effect of the combination of vitamin A and VCR was also tested in vivo on the life-span of mice bearing P388/S or P388/VCR. Intraperitoneal administration of retinyl palmitate at 41.75 or 83.5 mg kg-1 was effective to potentiate the antileukaemic activity of VCR against P388/S bearing mice, and it also overcame vincristine-resistance in P388/VCR bearing mice.
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spelling pubmed-20021912009-09-10 Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells. Nogae, I. Kikuchi, J. Yamaguchi, T. Nakagawa, M. Shiraishi, N. Kuwano, M. Br J Cancer Research Article Vitamin A has been shown to potentiate the cytotoxic action of anticancer agents like vincristine (VCR) against drug resistant mouse P388 leukaemia cells. In vitro tests showed enhancement by retinyl acetate of cytocidal activities of VCR against drug-sensitive leukaemia (P388/S) and VCR-resistant leukaemia (P388/VCR) cells in culture; retinyl acetate rather specifically potentiated VCR against cultured P388/VCR cells than P388/S cells. The cellular accumulation of radioactive VCR was significantly enhanced in cultured P388/VCR cells when retinyl acetate was present. The efflux of VCR from drug-resistant cells was blocked by retinyl acetate. The effect of the combination of vitamin A and VCR was also tested in vivo on the life-span of mice bearing P388/S or P388/VCR. Intraperitoneal administration of retinyl palmitate at 41.75 or 83.5 mg kg-1 was effective to potentiate the antileukaemic activity of VCR against P388/S bearing mice, and it also overcame vincristine-resistance in P388/VCR bearing mice. Nature Publishing Group 1987-09 /pmc/articles/PMC2002191/ /pubmed/3663474 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Nogae, I.
Kikuchi, J.
Yamaguchi, T.
Nakagawa, M.
Shiraishi, N.
Kuwano, M.
Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.
title Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.
title_full Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.
title_fullStr Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.
title_full_unstemmed Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.
title_short Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells.
title_sort potentiation of vincristine by vitamin a against drug-resistant mouse leukaemia cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002191/
https://www.ncbi.nlm.nih.gov/pubmed/3663474
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