Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.

Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunop...

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Autores principales: Underwood, J. C., Giri, D. D., Rooney, N., Lonsdale, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002391/
https://www.ncbi.nlm.nih.gov/pubmed/3435700
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author Underwood, J. C.
Giri, D. D.
Rooney, N.
Lonsdale, R.
author_facet Underwood, J. C.
Giri, D. D.
Rooney, N.
Lonsdale, R.
author_sort Underwood, J. C.
collection PubMed
description Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunophenotype of the infiltrating lymphoid cells and related this to the tumour ER content. There is a significant inverse correlation between the presence of Leu7-positive cells, which includes a subpopulation of natural killer (NK) cells, and tumour ER content; this is possibly superimposed on the dilutional effect of macrophages and other infiltrating cells. IMAGES:
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spelling pubmed-20023912009-09-10 Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content. Underwood, J. C. Giri, D. D. Rooney, N. Lonsdale, R. Br J Cancer Research Article Several studies of breast tumour histology and oestrogen receptor (ER) contents report an inverse correlation between the density of the stromal lymphoid cell infiltrate and the presence or concentration of ER. Using monoclonal antibodies to lymphoid cell surface markers we have examined the immunophenotype of the infiltrating lymphoid cells and related this to the tumour ER content. There is a significant inverse correlation between the presence of Leu7-positive cells, which includes a subpopulation of natural killer (NK) cells, and tumour ER content; this is possibly superimposed on the dilutional effect of macrophages and other infiltrating cells. IMAGES: Nature Publishing Group 1987-12 /pmc/articles/PMC2002391/ /pubmed/3435700 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Underwood, J. C.
Giri, D. D.
Rooney, N.
Lonsdale, R.
Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.
title Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.
title_full Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.
title_fullStr Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.
title_full_unstemmed Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.
title_short Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.
title_sort immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002391/
https://www.ncbi.nlm.nih.gov/pubmed/3435700
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