Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.

Two P388 cell lines with acquired resistance to daunorubicin have been shown to exhibit cross-resistance to anthrapyrazolone (NSC 357885). The degree of cross-resistance observed in these cell lines (58 and 150 fold) is similar to those observed towards daunorubicin (34 and 142 fold). However the de...

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Detalles Bibliográficos
Autores principales: McGown, A., Poppitt, D. G., Fox, B. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002408/
https://www.ncbi.nlm.nih.gov/pubmed/3435702
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author McGown, A.
Poppitt, D. G.
Fox, B. W.
author_facet McGown, A.
Poppitt, D. G.
Fox, B. W.
author_sort McGown, A.
collection PubMed
description Two P388 cell lines with acquired resistance to daunorubicin have been shown to exhibit cross-resistance to anthrapyrazolone (NSC 357885). The degree of cross-resistance observed in these cell lines (58 and 150 fold) is similar to those observed towards daunorubicin (34 and 142 fold). However the decreased drug accumulation observed for daunorubicin in the resistant cell lines (4-6 fold) is not observed for anthrapyrazolone. Similarly, verapamil can increase daunorubicin accumulation in resistant cells but has no effect on anthrapyrazolone accumulation. It is concluded that in contrast to daunorubicin, decreased anthrapyrazolone accumulation is not the resistance mechanism operative in daunorubicin resistant cell lines towards anthrapyrazolone.
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spelling pubmed-20024082009-09-10 Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines. McGown, A. Poppitt, D. G. Fox, B. W. Br J Cancer Research Article Two P388 cell lines with acquired resistance to daunorubicin have been shown to exhibit cross-resistance to anthrapyrazolone (NSC 357885). The degree of cross-resistance observed in these cell lines (58 and 150 fold) is similar to those observed towards daunorubicin (34 and 142 fold). However the decreased drug accumulation observed for daunorubicin in the resistant cell lines (4-6 fold) is not observed for anthrapyrazolone. Similarly, verapamil can increase daunorubicin accumulation in resistant cells but has no effect on anthrapyrazolone accumulation. It is concluded that in contrast to daunorubicin, decreased anthrapyrazolone accumulation is not the resistance mechanism operative in daunorubicin resistant cell lines towards anthrapyrazolone. Nature Publishing Group 1987-12 /pmc/articles/PMC2002408/ /pubmed/3435702 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McGown, A.
Poppitt, D. G.
Fox, B. W.
Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
title Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
title_full Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
title_fullStr Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
title_full_unstemmed Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
title_short Comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
title_sort comparison of daunorubicin and anthrapyrazolone sensitivity and transport in resistant cell lines.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002408/
https://www.ncbi.nlm.nih.gov/pubmed/3435702
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