Site-Directed Mutations in the C-Terminal Extension of Human αB-Crystallin Affect Chaperone Function and Block Amyloid Fibril Formation

BACKGROUND: Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate protein deposition and ordered amyloid fibril assembly. Molecular chaperones, including αB-crystallin, play a role in the prevention of protein deposition. METHODOLOGY/PRINCIPAL FINDINGS: A...

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Detalles Bibliográficos
Autores principales: Treweek, Teresa M., Ecroyd, Heath, Williams, Danielle M., Meehan, Sarah, Carver, John A., Walker, Mark J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002509/
https://www.ncbi.nlm.nih.gov/pubmed/17940610
http://dx.doi.org/10.1371/journal.pone.0001046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002509/
https://www.ncbi.nlm.nih.gov/pubmed/17940610
http://dx.doi.org/10.1371/journal.pone.0001046

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