Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments

Further investigations into the mechanism by which CCl(4) administration to Sprague-Dawley rats protects them against the adrenocorticolytic action of dimethylbenz(a)anthracene (DMBA) are reported. The results show that CCl(4) must be given shortly before DMBA to achieve the best protection and that...

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Autores principales: Wheatley, D. N., Gerrard, M. E., Kernohan, I. R., Currie, A. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008441/
https://www.ncbi.nlm.nih.gov/pubmed/4624907
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author Wheatley, D. N.
Gerrard, M. E.
Kernohan, I. R.
Currie, A. R.
author_facet Wheatley, D. N.
Gerrard, M. E.
Kernohan, I. R.
Currie, A. R.
author_sort Wheatley, D. N.
collection PubMed
description Further investigations into the mechanism by which CCl(4) administration to Sprague-Dawley rats protects them against the adrenocorticolytic action of dimethylbenz(a)anthracene (DMBA) are reported. The results show that CCl(4) must be given shortly before DMBA to achieve the best protection and that treatments given after DMBA are ineffective. It was established that the hepatotoxicity of CCl(4) in these experiments was related reciprocally to the adrenocorticolytic effect of DMBA. Protection with butter yellow (DAB) was achieved only when sufficient time elapses for drug metabolism to be stimulated in the liver. Butter yellow given after DMBA has no protective effect but the prior exposure of the rats to DMBA potentiates the hepatotoxic effects of DAB. Partial hepatectomy gives protection when performed 1 day before DMBA; shorter intervals give no protection. Some protection can be achieved with resection 6 or 24 hours after DMBA. IMAGES:
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spelling pubmed-20084412009-09-10 Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments Wheatley, D. N. Gerrard, M. E. Kernohan, I. R. Currie, A. R. Br J Cancer Articles Further investigations into the mechanism by which CCl(4) administration to Sprague-Dawley rats protects them against the adrenocorticolytic action of dimethylbenz(a)anthracene (DMBA) are reported. The results show that CCl(4) must be given shortly before DMBA to achieve the best protection and that treatments given after DMBA are ineffective. It was established that the hepatotoxicity of CCl(4) in these experiments was related reciprocally to the adrenocorticolytic effect of DMBA. Protection with butter yellow (DAB) was achieved only when sufficient time elapses for drug metabolism to be stimulated in the liver. Butter yellow given after DMBA has no protective effect but the prior exposure of the rats to DMBA potentiates the hepatotoxic effects of DAB. Partial hepatectomy gives protection when performed 1 day before DMBA; shorter intervals give no protection. Some protection can be achieved with resection 6 or 24 hours after DMBA. IMAGES: Nature Publishing Group 1972-04 /pmc/articles/PMC2008441/ /pubmed/4624907 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Wheatley, D. N.
Gerrard, M. E.
Kernohan, I. R.
Currie, A. R.
Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments
title Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments
title_full Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments
title_fullStr Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments
title_full_unstemmed Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments
title_short Reciprocal Relationship Between the Production of Adrenal Damage by 7,12-Dimethylbenz(a)anthracene in Rats and the Induction of Liver Damage by Various Treatments
title_sort reciprocal relationship between the production of adrenal damage by 7,12-dimethylbenz(a)anthracene in rats and the induction of liver damage by various treatments
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008441/
https://www.ncbi.nlm.nih.gov/pubmed/4624907
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