Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma

A 17-year-old patient with a small paratesticular embryonic sarcoma presented with symptoms of renal failure, polyuria and widespread bone metastases. Investigation revealed hypercalcaemia and uraemia without any evidence of hyperparathyroidism. The hypercalcaemia responded over a period of weeks to...

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Detalles Bibliográficos
Autores principales: Parsons, V., Scott, G., Baum, M., Molland, E., Makin, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1971
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008444/
https://www.ncbi.nlm.nih.gov/pubmed/4256008
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author Parsons, V.
Scott, G.
Baum, M.
Molland, E.
Makin, J.
author_facet Parsons, V.
Scott, G.
Baum, M.
Molland, E.
Makin, J.
author_sort Parsons, V.
collection PubMed
description A 17-year-old patient with a small paratesticular embryonic sarcoma presented with symptoms of renal failure, polyuria and widespread bone metastases. Investigation revealed hypercalcaemia and uraemia without any evidence of hyperparathyroidism. The hypercalcaemia responded over a period of weeks to administration of mithramycin with initial improvement in the symptoms and metabolic derangements. Control was lost with the necrosis of intra-abdominal tumour deposits and haemorrhagic polypoid deposits in the alimentary tract. The value and hazards of mithramycin are well demonstrated by these rare complications of this type of tumour. IMAGES:
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spelling pubmed-20084442009-09-10 Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma Parsons, V. Scott, G. Baum, M. Molland, E. Makin, J. Br J Cancer Articles A 17-year-old patient with a small paratesticular embryonic sarcoma presented with symptoms of renal failure, polyuria and widespread bone metastases. Investigation revealed hypercalcaemia and uraemia without any evidence of hyperparathyroidism. The hypercalcaemia responded over a period of weeks to administration of mithramycin with initial improvement in the symptoms and metabolic derangements. Control was lost with the necrosis of intra-abdominal tumour deposits and haemorrhagic polypoid deposits in the alimentary tract. The value and hazards of mithramycin are well demonstrated by these rare complications of this type of tumour. IMAGES: Nature Publishing Group 1971-06 /pmc/articles/PMC2008444/ /pubmed/4256008 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Parsons, V.
Scott, G.
Baum, M.
Molland, E.
Makin, J.
Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma
title Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma
title_full Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma
title_fullStr Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma
title_full_unstemmed Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma
title_short Mithramycin Treatment of Hypercalcaemia and Renal Failure in a Patient with Paratesticular Embryonic Sarcoma
title_sort mithramycin treatment of hypercalcaemia and renal failure in a patient with paratesticular embryonic sarcoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008444/
https://www.ncbi.nlm.nih.gov/pubmed/4256008
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