The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus

Single intraperitoneal injections of dimethylnitrosamine (DMN) in concentrations of up to 16 mg/g body weight, failed to have any lethal effect in newts. This treatment also failed to induce tumours in newts maintained for one year after injection. Six or 7 injections of 16 mg/g body weight of DMN,...

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Autor principal: Ingram, Andrew J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008475/
https://www.ncbi.nlm.nih.gov/pubmed/5047143
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author Ingram, Andrew J.
author_facet Ingram, Andrew J.
author_sort Ingram, Andrew J.
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description Single intraperitoneal injections of dimethylnitrosamine (DMN) in concentrations of up to 16 mg/g body weight, failed to have any lethal effect in newts. This treatment also failed to induce tumours in newts maintained for one year after injection. Six or 7 injections of 16 mg/g body weight of DMN, administered over a period of 3-4 weeks, gave rise to a short-term lethal effect due to liver necrosis and in the long term to liver tumours. The tumours induced were of similar type to nitrosamineinduced tumours in rats, one being an anaplastic liver tumour and the other nodular hepatic cell tumours. Attempts to maintain the tumours by grafting failed, probably due to homograft rejection. IMAGES:
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spelling pubmed-20084752009-09-10 The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus Ingram, Andrew J. Br J Cancer Articles Single intraperitoneal injections of dimethylnitrosamine (DMN) in concentrations of up to 16 mg/g body weight, failed to have any lethal effect in newts. This treatment also failed to induce tumours in newts maintained for one year after injection. Six or 7 injections of 16 mg/g body weight of DMN, administered over a period of 3-4 weeks, gave rise to a short-term lethal effect due to liver necrosis and in the long term to liver tumours. The tumours induced were of similar type to nitrosamineinduced tumours in rats, one being an anaplastic liver tumour and the other nodular hepatic cell tumours. Attempts to maintain the tumours by grafting failed, probably due to homograft rejection. IMAGES: Nature Publishing Group 1972-06 /pmc/articles/PMC2008475/ /pubmed/5047143 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Ingram, Andrew J.
The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus
title The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus
title_full The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus
title_fullStr The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus
title_full_unstemmed The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus
title_short The Lethal and Hepatocarcinogenic Effects of Dimethylnitrosamine Injection in the Newt Triturus Helveticus
title_sort lethal and hepatocarcinogenic effects of dimethylnitrosamine injection in the newt triturus helveticus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008475/
https://www.ncbi.nlm.nih.gov/pubmed/5047143
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