A Kinetic Study On Murine Myeloid Leukaemia

A kinetic study was made on murine myeloid leukaemia, using the myeloid leukaemia colony in the spleen as a model system. The number of myeloid leukaemia colony-forming units (MLCFU) recoverable from the bone marrow, spleen and liver increased exponentially as a function of time from day 1 up to day...

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Detalles Bibliográficos
Autores principales: Tanaka, T., Craig, A. W., Lajtha, L. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008514/
https://www.ncbi.nlm.nih.gov/pubmed/5269878
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author Tanaka, T.
Craig, A. W.
Lajtha, L. G.
author_facet Tanaka, T.
Craig, A. W.
Lajtha, L. G.
author_sort Tanaka, T.
collection PubMed
description A kinetic study was made on murine myeloid leukaemia, using the myeloid leukaemia colony in the spleen as a model system. The number of myeloid leukaemia colony-forming units (MLCFU) recoverable from the bone marrow, spleen and liver increased exponentially as a function of time from day 1 up to day 9, after the initial lag period of 12-24 hours. The f-values were estimated to be about 67 per cent in the above 3 organs. After day 10, the number of MLCFU declined in these organs. The myeloid leukaemia was sensitive to cyclophosphamide and chlorambucil, as determined by the slopes of the survival curves obtained for MLCFU. Finally, an entity of the mixed type in the myeloid leukaemia colony was described. IMAGES:
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spelling pubmed-20085142009-09-10 A Kinetic Study On Murine Myeloid Leukaemia Tanaka, T. Craig, A. W. Lajtha, L. G. Br J Cancer Articles A kinetic study was made on murine myeloid leukaemia, using the myeloid leukaemia colony in the spleen as a model system. The number of myeloid leukaemia colony-forming units (MLCFU) recoverable from the bone marrow, spleen and liver increased exponentially as a function of time from day 1 up to day 9, after the initial lag period of 12-24 hours. The f-values were estimated to be about 67 per cent in the above 3 organs. After day 10, the number of MLCFU declined in these organs. The myeloid leukaemia was sensitive to cyclophosphamide and chlorambucil, as determined by the slopes of the survival curves obtained for MLCFU. Finally, an entity of the mixed type in the myeloid leukaemia colony was described. IMAGES: Nature Publishing Group 1970-03 /pmc/articles/PMC2008514/ /pubmed/5269878 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Tanaka, T.
Craig, A. W.
Lajtha, L. G.
A Kinetic Study On Murine Myeloid Leukaemia
title A Kinetic Study On Murine Myeloid Leukaemia
title_full A Kinetic Study On Murine Myeloid Leukaemia
title_fullStr A Kinetic Study On Murine Myeloid Leukaemia
title_full_unstemmed A Kinetic Study On Murine Myeloid Leukaemia
title_short A Kinetic Study On Murine Myeloid Leukaemia
title_sort kinetic study on murine myeloid leukaemia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008514/
https://www.ncbi.nlm.nih.gov/pubmed/5269878
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