The Effects of Castration on the Induction of Experimental Gliomas in Male Rats

Pellets of 3,4-benzopyrene were implanted into the brain of equal numbers of normal and castrated male rats. The position of the implant was carefully controlled so that it impinged on the mitotically active sub-ependymal plate. A high proportion of glial tumours (77.8%) were induced in normal male...

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Detalles Bibliográficos
Autor principal: Hopewell, J. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008517/
https://www.ncbi.nlm.nih.gov/pubmed/5428613
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author Hopewell, J. W.
author_facet Hopewell, J. W.
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description Pellets of 3,4-benzopyrene were implanted into the brain of equal numbers of normal and castrated male rats. The position of the implant was carefully controlled so that it impinged on the mitotically active sub-ependymal plate. A high proportion of glial tumours (77.8%) were induced in normal male rats. The effects of castration were to reduce the incidence of tumoures (50%) and to increase the time interval between implantation and death from cerebral tumour. The implications from these results, as to the possible roles of testosterone, are discussed.
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spelling pubmed-20085172009-09-10 The Effects of Castration on the Induction of Experimental Gliomas in Male Rats Hopewell, J. W. Br J Cancer Articles Pellets of 3,4-benzopyrene were implanted into the brain of equal numbers of normal and castrated male rats. The position of the implant was carefully controlled so that it impinged on the mitotically active sub-ependymal plate. A high proportion of glial tumours (77.8%) were induced in normal male rats. The effects of castration were to reduce the incidence of tumoures (50%) and to increase the time interval between implantation and death from cerebral tumour. The implications from these results, as to the possible roles of testosterone, are discussed. Nature Publishing Group 1970-03 /pmc/articles/PMC2008517/ /pubmed/5428613 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Hopewell, J. W.
The Effects of Castration on the Induction of Experimental Gliomas in Male Rats
title The Effects of Castration on the Induction of Experimental Gliomas in Male Rats
title_full The Effects of Castration on the Induction of Experimental Gliomas in Male Rats
title_fullStr The Effects of Castration on the Induction of Experimental Gliomas in Male Rats
title_full_unstemmed The Effects of Castration on the Induction of Experimental Gliomas in Male Rats
title_short The Effects of Castration on the Induction of Experimental Gliomas in Male Rats
title_sort effects of castration on the induction of experimental gliomas in male rats
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008517/
https://www.ncbi.nlm.nih.gov/pubmed/5428613
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