6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine

The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory ac...

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Detalles Bibliográficos
Autores principales: Price, D. J., Timson, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1971
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008542/
https://www.ncbi.nlm.nih.gov/pubmed/5581289
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author Price, D. J.
Timson, J.
author_facet Price, D. J.
Timson, J.
author_sort Price, D. J.
collection PubMed
description The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase.
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spelling pubmed-20085422009-09-10 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine Price, D. J. Timson, J. Br J Cancer Articles The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase. Nature Publishing Group 1971-03 /pmc/articles/PMC2008542/ /pubmed/5581289 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Price, D. J.
Timson, J.
6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
title 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
title_full 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
title_fullStr 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
title_full_unstemmed 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
title_short 6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
title_sort 6-thioguanine: antimitotic effect on human lymphocytes in vitro prevented by adenine
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008542/
https://www.ncbi.nlm.nih.gov/pubmed/5581289
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