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Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour
When normal rat and mouse embryo cells were treated with a cell free extract of S37 ascites tumour, morphological transformations occurred in both. The transformed cells readily induced lymphosarcoma-type tumours in the mice inoculated when newborn or young adults (8-12 weeks old), but not so readil...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1971
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008549/ https://www.ncbi.nlm.nih.gov/pubmed/4325684 |
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author | Rasheed, S. |
author_facet | Rasheed, S. |
author_sort | Rasheed, S. |
collection | PubMed |
description | When normal rat and mouse embryo cells were treated with a cell free extract of S37 ascites tumour, morphological transformations occurred in both. The transformed cells readily induced lymphosarcoma-type tumours in the mice inoculated when newborn or young adults (8-12 weeks old), but not so readily in rats. Various tests carried out with these cells strongly indicate the presence of an oncogenic and transmissible agent in S37 ascites tumour. This agent appears to be related to mouse sarcoma virus isolated from animals with Moloney leukaemia but differs in only producing characteristic lymphosarcoma-type tumours. IMAGES: |
format | Text |
id | pubmed-2008549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1971 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20085492009-09-10 Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour Rasheed, S. Br J Cancer Articles When normal rat and mouse embryo cells were treated with a cell free extract of S37 ascites tumour, morphological transformations occurred in both. The transformed cells readily induced lymphosarcoma-type tumours in the mice inoculated when newborn or young adults (8-12 weeks old), but not so readily in rats. Various tests carried out with these cells strongly indicate the presence of an oncogenic and transmissible agent in S37 ascites tumour. This agent appears to be related to mouse sarcoma virus isolated from animals with Moloney leukaemia but differs in only producing characteristic lymphosarcoma-type tumours. IMAGES: Nature Publishing Group 1971-03 /pmc/articles/PMC2008549/ /pubmed/4325684 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Articles Rasheed, S. Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour |
title | Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour |
title_full | Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour |
title_fullStr | Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour |
title_full_unstemmed | Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour |
title_short | Morphological Transformation of Mouse and Rat Embryo Cells in vitro by an Agent from S37 Ascites Tumour |
title_sort | morphological transformation of mouse and rat embryo cells in vitro by an agent from s37 ascites tumour |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008549/ https://www.ncbi.nlm.nih.gov/pubmed/4325684 |
work_keys_str_mv | AT rasheeds morphologicaltransformationofmouseandratembryocellsinvitrobyanagentfroms37ascitestumour |