The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard

The effect of cysteine on the immunosuppressive activity of three alkylating agents was tested. Cysteine strongly inhibited the ability of cyclophosphamide and nitrogen mustard to depress the direct plaque-forming cell response of mice to sheep red cells. In contrast, the activity of busulphan was u...

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Detalles Bibliográficos
Autores principales: Addison, I. E., Berenbaum, M. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1971
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008554/
https://www.ncbi.nlm.nih.gov/pubmed/4932848
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author Addison, I. E.
Berenbaum, M. C.
author_facet Addison, I. E.
Berenbaum, M. C.
author_sort Addison, I. E.
collection PubMed
description The effect of cysteine on the immunosuppressive activity of three alkylating agents was tested. Cysteine strongly inhibited the ability of cyclophosphamide and nitrogen mustard to depress the direct plaque-forming cell response of mice to sheep red cells. In contrast, the activity of busulphan was usually potentiated by administration of cysteine. This throws doubt on the hypothesis that busulphan exerts its cytotoxic effects by alkylating thiol groups.
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spelling pubmed-20085542009-09-10 The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard Addison, I. E. Berenbaum, M. C. Br J Cancer Articles The effect of cysteine on the immunosuppressive activity of three alkylating agents was tested. Cysteine strongly inhibited the ability of cyclophosphamide and nitrogen mustard to depress the direct plaque-forming cell response of mice to sheep red cells. In contrast, the activity of busulphan was usually potentiated by administration of cysteine. This throws doubt on the hypothesis that busulphan exerts its cytotoxic effects by alkylating thiol groups. Nature Publishing Group 1971-03 /pmc/articles/PMC2008554/ /pubmed/4932848 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Addison, I. E.
Berenbaum, M. C.
The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard
title The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard
title_full The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard
title_fullStr The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard
title_full_unstemmed The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard
title_short The Effect of Cysteine on the Immunosuppressive Activity of Busulphan, Cyclophosphamide and Nitrogen Mustard
title_sort effect of cysteine on the immunosuppressive activity of busulphan, cyclophosphamide and nitrogen mustard
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008554/
https://www.ncbi.nlm.nih.gov/pubmed/4932848
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