Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour

A possible basis for the differences in malignancy between three closely related sublines of the WBP1 ascites tumour of the rat has been studied by examining the biochemical changes in rat sera during tumour growth in vivo. Death appeared to be due to hypoglycaemia and the ability to induce this con...

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Detalles Bibliográficos
Autores principales: Killington, R. A., Williams, A. E., Ratcliffe, N. A., Whitehead, T. P., Smith, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1971
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008555/
https://www.ncbi.nlm.nih.gov/pubmed/5581305
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author Killington, R. A.
Williams, A. E.
Ratcliffe, N. A.
Whitehead, T. P.
Smith, H.
author_facet Killington, R. A.
Williams, A. E.
Ratcliffe, N. A.
Whitehead, T. P.
Smith, H.
author_sort Killington, R. A.
collection PubMed
description A possible basis for the differences in malignancy between three closely related sublines of the WBP1 ascites tumour of the rat has been studied by examining the biochemical changes in rat sera during tumour growth in vivo. Death appeared to be due to hypoglycaemia and the ability to induce this condition correlated with the differences in malignancy between the sublines; WBP1 (X) and WBP1 (V), the more malignant sublines, inducing hypoglycaemia earlier and more rapidly than the least malignant subline WBP1 (A). Possible mechanisms whereby the tumour produces these effects are discussed.
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spelling pubmed-20085552009-09-10 Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour Killington, R. A. Williams, A. E. Ratcliffe, N. A. Whitehead, T. P. Smith, H. Br J Cancer Articles A possible basis for the differences in malignancy between three closely related sublines of the WBP1 ascites tumour of the rat has been studied by examining the biochemical changes in rat sera during tumour growth in vivo. Death appeared to be due to hypoglycaemia and the ability to induce this condition correlated with the differences in malignancy between the sublines; WBP1 (X) and WBP1 (V), the more malignant sublines, inducing hypoglycaemia earlier and more rapidly than the least malignant subline WBP1 (A). Possible mechanisms whereby the tumour produces these effects are discussed. Nature Publishing Group 1971-03 /pmc/articles/PMC2008555/ /pubmed/5581305 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Killington, R. A.
Williams, A. E.
Ratcliffe, N. A.
Whitehead, T. P.
Smith, H.
Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour
title Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour
title_full Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour
title_fullStr Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour
title_full_unstemmed Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour
title_short Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour
title_sort hypoglycaemia and malignancy differences of closely related sublines of a rat tumour
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008555/
https://www.ncbi.nlm.nih.gov/pubmed/5581305
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