Comparative Effects of Heating and Fasting in Mice, with Particular Reference to Development of Sarcoma 180

Effects of heating and fasting, both alone and associated, have been studied in normal and Sarcoma 180 bearing mice. Heating reduced body weight and tumour mass and increased body temperature. Fasting reduced body weight, while tumour mass and body temperature were slightly affected. By associating heating and fasting a more marked decrease of body weight was produced than by each of the two factors involved, while effects on body temperature and on tumour mass were unchanged with respect to heating alone. 6-mercaptopurine was similar to heating in reducing body weight and tumour mass.