Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs

It has been shown that when (32)P counting from a tumour is continuous peaks in the count rate can sometimes be induced by large doses of nicotinic acid, nicotinic acid, nicotinamide or 3-acetylpyridine, but not by 6-aminonicotinamide. These (32)P counting peaks have been associated with the time of...

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Autores principales: Calcutt, G., Ting, S. M., Preece, A. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008568/
https://www.ncbi.nlm.nih.gov/pubmed/4317987
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author Calcutt, G.
Ting, S. M.
Preece, A. W.
author_facet Calcutt, G.
Ting, S. M.
Preece, A. W.
author_sort Calcutt, G.
collection PubMed
description It has been shown that when (32)P counting from a tumour is continuous peaks in the count rate can sometimes be induced by large doses of nicotinic acid, nicotinic acid, nicotinamide or 3-acetylpyridine, but not by 6-aminonicotinamide. These (32)P counting peaks have been associated with the time of maximal new synthesis of nicotinamide adenine dinucleotide (NAD). Sensitization to irradiation or some cytotoxic drugs has been found at the peak of this new NAD synthesis. The radioprotective agents cysteamine, 2-aminoethylisothiouronium bromide (AET) and serotonin have been found to cause a rapid fall in tissue NAD levels. The results have been briefly discussed. IMAGES:
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spelling pubmed-20085682009-09-10 Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs Calcutt, G. Ting, S. M. Preece, A. W. Br J Cancer Articles It has been shown that when (32)P counting from a tumour is continuous peaks in the count rate can sometimes be induced by large doses of nicotinic acid, nicotinic acid, nicotinamide or 3-acetylpyridine, but not by 6-aminonicotinamide. These (32)P counting peaks have been associated with the time of maximal new synthesis of nicotinamide adenine dinucleotide (NAD). Sensitization to irradiation or some cytotoxic drugs has been found at the peak of this new NAD synthesis. The radioprotective agents cysteamine, 2-aminoethylisothiouronium bromide (AET) and serotonin have been found to cause a rapid fall in tissue NAD levels. The results have been briefly discussed. IMAGES: Nature Publishing Group 1970-06 /pmc/articles/PMC2008568/ /pubmed/4317987 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Calcutt, G.
Ting, S. M.
Preece, A. W.
Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs
title Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs
title_full Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs
title_fullStr Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs
title_full_unstemmed Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs
title_short Tissue NAD Levels and the Response to Irradiation or Cytotoxic Drugs
title_sort tissue nad levels and the response to irradiation or cytotoxic drugs
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008568/
https://www.ncbi.nlm.nih.gov/pubmed/4317987
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