Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia

Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Adam, M., Thorburn, Marigold J., Gibbs, W. N., Brooks, S. E. H., Hanchard, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008570/
https://www.ncbi.nlm.nih.gov/pubmed/4393772
Descripción
Sumario:Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in the light of previous cytogenetic studies of lymphoreticular neoplasia and autoimmune disease and the relationship between these two conditions. IMAGES:

Ejemplares similares