Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia

Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in th...

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Autores principales: Adam, M., Thorburn, Marigold J., Gibbs, W. N., Brooks, S. E. H., Hanchard, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008570/
https://www.ncbi.nlm.nih.gov/pubmed/4393772
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author Adam, M.
Thorburn, Marigold J.
Gibbs, W. N.
Brooks, S. E. H.
Hanchard, B.
author_facet Adam, M.
Thorburn, Marigold J.
Gibbs, W. N.
Brooks, S. E. H.
Hanchard, B.
author_sort Adam, M.
collection PubMed
description Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in the light of previous cytogenetic studies of lymphoreticular neoplasia and autoimmune disease and the relationship between these two conditions. IMAGES:
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spelling pubmed-20085702009-09-10 Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia Adam, M. Thorburn, Marigold J. Gibbs, W. N. Brooks, S. E. H. Hanchard, B. Br J Cancer Articles Two cases are described, one with proven lymphosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in the light of previous cytogenetic studies of lymphoreticular neoplasia and autoimmune disease and the relationship between these two conditions. IMAGES: Nature Publishing Group 1970-06 /pmc/articles/PMC2008570/ /pubmed/4393772 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Adam, M.
Thorburn, Marigold J.
Gibbs, W. N.
Brooks, S. E. H.
Hanchard, B.
Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia
title Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia
title_full Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia
title_fullStr Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia
title_full_unstemmed Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia
title_short Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia
title_sort clonal evolution in two patients with autoimmune disease and lymphoreticular neoplasia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008570/
https://www.ncbi.nlm.nih.gov/pubmed/4393772
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