The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle

Sprague-Dawley rats aged 50 days were given single oral doses of the carcinogen, DMBA. Rats receiving the carcinogen at the same stage of the oestrous cycle were grouped together and mammary tumour production was compared between these groups. When the carcinogen was given during di-oestrus the mean...

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Autores principales: Young, Stretton, Cowan, Dorothea M., Davidson, Christine
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008581/
https://www.ncbi.nlm.nih.gov/pubmed/5465532
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author Young, Stretton
Cowan, Dorothea M.
Davidson, Christine
author_facet Young, Stretton
Cowan, Dorothea M.
Davidson, Christine
author_sort Young, Stretton
collection PubMed
description Sprague-Dawley rats aged 50 days were given single oral doses of the carcinogen, DMBA. Rats receiving the carcinogen at the same stage of the oestrous cycle were grouped together and mammary tumour production was compared between these groups. When the carcinogen was given during di-oestrus the mean number of tumours per animal was significantly greater than when it was given at other stages in the oestrous cycle. There was considerable variation in total tumour yield from one batch of animals to another.
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spelling pubmed-20085812009-09-10 The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle Young, Stretton Cowan, Dorothea M. Davidson, Christine Br J Cancer Articles Sprague-Dawley rats aged 50 days were given single oral doses of the carcinogen, DMBA. Rats receiving the carcinogen at the same stage of the oestrous cycle were grouped together and mammary tumour production was compared between these groups. When the carcinogen was given during di-oestrus the mean number of tumours per animal was significantly greater than when it was given at other stages in the oestrous cycle. There was considerable variation in total tumour yield from one batch of animals to another. Nature Publishing Group 1970-06 /pmc/articles/PMC2008581/ /pubmed/5465532 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Young, Stretton
Cowan, Dorothea M.
Davidson, Christine
The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle
title The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle
title_full The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle
title_fullStr The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle
title_full_unstemmed The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle
title_short The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle
title_sort production of mammary carcinomas in rats by 9,10-dimethyl-1,2-benzanthracene and its relationship to the oestrous cycle
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008581/
https://www.ncbi.nlm.nih.gov/pubmed/5465532
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