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Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcom...
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| Formato: | Texto |
| Lenguaje: | English |
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Nature Publishing Group
1970
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008590/ https://www.ncbi.nlm.nih.gov/pubmed/5271271 |
| Sumario: | A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the “spontaneous” osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed. IMAGES: |
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