Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man

A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcom...

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Detalles Bibliográficos
Autor principal: Cobb, L. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008590/
https://www.ncbi.nlm.nih.gov/pubmed/5271271
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author Cobb, L. M.
author_facet Cobb, L. M.
author_sort Cobb, L. M.
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description A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the “spontaneous” osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed. IMAGES:
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spelling pubmed-20085902009-09-10 Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man Cobb, L. M. Br J Cancer Articles A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the “spontaneous” osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed. IMAGES: Nature Publishing Group 1970-06 /pmc/articles/PMC2008590/ /pubmed/5271271 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Cobb, L. M.
Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
title Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
title_full Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
title_fullStr Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
title_full_unstemmed Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
title_short Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man
title_sort radiation-induced osteosarcoma in the rat as a model for osteosarcoma in man
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008590/
https://www.ncbi.nlm.nih.gov/pubmed/5271271
work_keys_str_mv AT cobblm radiationinducedosteosarcomaintheratasamodelforosteosarcomainman

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