Enzyme and Isoenzyme Alterations in Friend Disease

The activities of certain enzymes in the tissus of mice infected with Friend virus have been studied. Progressive increases in LDH, G6PDH and 6PGDH have been observed in the spleen and liver concomitant with malignant transformation. Plasma LDH activity was also observed to increase over the period...

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Detalles Bibliográficos
Autores principales: Turner, D. M., Dawson, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008593/
https://www.ncbi.nlm.nih.gov/pubmed/5451576
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author Turner, D. M.
Dawson, P. J.
author_facet Turner, D. M.
Dawson, P. J.
author_sort Turner, D. M.
collection PubMed
description The activities of certain enzymes in the tissus of mice infected with Friend virus have been studied. Progressive increases in LDH, G6PDH and 6PGDH have been observed in the spleen and liver concomitant with malignant transformation. Plasma LDH activity was also observed to increase over the period of study, but changes in the isoenzyme distribution probably resulted from contamination of the Friend virus preparation with lactic dehydrogenase virus. The tissue enzyme changes are similar to those observed in human malignancies. IMAGES:
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spelling pubmed-20085932009-09-10 Enzyme and Isoenzyme Alterations in Friend Disease Turner, D. M. Dawson, P. J. Br J Cancer Articles The activities of certain enzymes in the tissus of mice infected with Friend virus have been studied. Progressive increases in LDH, G6PDH and 6PGDH have been observed in the spleen and liver concomitant with malignant transformation. Plasma LDH activity was also observed to increase over the period of study, but changes in the isoenzyme distribution probably resulted from contamination of the Friend virus preparation with lactic dehydrogenase virus. The tissue enzyme changes are similar to those observed in human malignancies. IMAGES: Nature Publishing Group 1970-06 /pmc/articles/PMC2008593/ /pubmed/5451576 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Turner, D. M.
Dawson, P. J.
Enzyme and Isoenzyme Alterations in Friend Disease
title Enzyme and Isoenzyme Alterations in Friend Disease
title_full Enzyme and Isoenzyme Alterations in Friend Disease
title_fullStr Enzyme and Isoenzyme Alterations in Friend Disease
title_full_unstemmed Enzyme and Isoenzyme Alterations in Friend Disease
title_short Enzyme and Isoenzyme Alterations in Friend Disease
title_sort enzyme and isoenzyme alterations in friend disease
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008593/
https://www.ncbi.nlm.nih.gov/pubmed/5451576
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