Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro

The present paper deals with the chromosomal DNA replication pattern in human solid tumour cells in vitro. This was studied at the terminal stages of the S-period. All the cell lines of female origin showed a late replicating chromosome in group XX6-12. In cell lines of male origin one of the chromo...

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Autor principal: Kucheria, Kiran
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008604/
https://www.ncbi.nlm.nih.gov/pubmed/5475754
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author Kucheria, Kiran
author_facet Kucheria, Kiran
author_sort Kucheria, Kiran
collection PubMed
description The present paper deals with the chromosomal DNA replication pattern in human solid tumour cells in vitro. This was studied at the terminal stages of the S-period. All the cell lines of female origin showed a late replicating chromosome in group XX6-12. In cell lines of male origin one of the chromosomes of group 21-22Y was later replicating than the rest of the members of the group. The DNA replication pattern of the autosomes and the sex chromosomes was similar to that of the cultured human leucocytes. The results of the present study show that the DNA replication pattern of the chromosome in neoplastic cells is basically unchanged despite the changes in the chromosome number and morphology. Therefore the abnormal behaviour of the neoplastic cells cannot be related to the changes in the pattern of the chromosomal DNA replication. IMAGES:
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spelling pubmed-20086042009-09-10 Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro Kucheria, Kiran Br J Cancer Articles The present paper deals with the chromosomal DNA replication pattern in human solid tumour cells in vitro. This was studied at the terminal stages of the S-period. All the cell lines of female origin showed a late replicating chromosome in group XX6-12. In cell lines of male origin one of the chromosomes of group 21-22Y was later replicating than the rest of the members of the group. The DNA replication pattern of the autosomes and the sex chromosomes was similar to that of the cultured human leucocytes. The results of the present study show that the DNA replication pattern of the chromosome in neoplastic cells is basically unchanged despite the changes in the chromosome number and morphology. Therefore the abnormal behaviour of the neoplastic cells cannot be related to the changes in the pattern of the chromosomal DNA replication. IMAGES: Nature Publishing Group 1970-09 /pmc/articles/PMC2008604/ /pubmed/5475754 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Kucheria, Kiran
Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro
title Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro
title_full Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro
title_fullStr Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro
title_full_unstemmed Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro
title_short Chromosomal DNA Replication Pattern in Human Tumour Cells in vitro
title_sort chromosomal dna replication pattern in human tumour cells in vitro
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008604/
https://www.ncbi.nlm.nih.gov/pubmed/5475754
work_keys_str_mv AT kucheriakiran chromosomaldnareplicationpatterninhumantumourcellsinvitro

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