Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)

Pretreatment with Metopirone (40 mg.) or SKF 525-A (2 mg./100 g. maternal body weight) protected aganist the embryotoxic and teratogenic actions of7-OHM-12-MBA) (2.5 mg/100 g. maternal body weight) in the Sprague-Dawley rat. At the doses administered SKF-525-A was a more efficient protector than Met...

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Detalles Bibliográficos
Autores principales: Bird, C. C., Crawford, Allison M., Currie, A. R., Stirling, B. Fiona
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008608/
https://www.ncbi.nlm.nih.gov/pubmed/5479302
Descripción
Sumario:Pretreatment with Metopirone (40 mg.) or SKF 525-A (2 mg./100 g. maternal body weight) protected aganist the embryotoxic and teratogenic actions of7-OHM-12-MBA) (2.5 mg/100 g. maternal body weight) in the Sprague-Dawley rat. At the doses administered SKF-525-A was a more efficient protector than Metopirone. The adrenocorticolytic actions of 7-OHM-12-MBA in the maternal adrenal glands were also prevented by these compounds and a close correlation existed between the degree of protection of the maternal adrenals and of the foetuses. It is suggested that the ultimate embryopathic substance is a metabolite of 7-OHM-12-MBA. IMAGES:

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