Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)

Pretreatment with Metopirone (40 mg.) or SKF 525-A (2 mg./100 g. maternal body weight) protected aganist the embryotoxic and teratogenic actions of7-OHM-12-MBA) (2.5 mg/100 g. maternal body weight) in the Sprague-Dawley rat. At the doses administered SKF-525-A was a more efficient protector than Met...

Descripción completa

Detalles Bibliográficos
Autores principales: Bird, C. C., Crawford, Allison M., Currie, A. R., Stirling, B. Fiona
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008608/
https://www.ncbi.nlm.nih.gov/pubmed/5479302
_version_ 1782135950430699520
author Bird, C. C.
Crawford, Allison M.
Currie, A. R.
Stirling, B. Fiona
author_facet Bird, C. C.
Crawford, Allison M.
Currie, A. R.
Stirling, B. Fiona
author_sort Bird, C. C.
collection PubMed
description Pretreatment with Metopirone (40 mg.) or SKF 525-A (2 mg./100 g. maternal body weight) protected aganist the embryotoxic and teratogenic actions of7-OHM-12-MBA) (2.5 mg/100 g. maternal body weight) in the Sprague-Dawley rat. At the doses administered SKF-525-A was a more efficient protector than Metopirone. The adrenocorticolytic actions of 7-OHM-12-MBA in the maternal adrenal glands were also prevented by these compounds and a close correlation existed between the degree of protection of the maternal adrenals and of the foetuses. It is suggested that the ultimate embryopathic substance is a metabolite of 7-OHM-12-MBA. IMAGES:
format Text
id pubmed-2008608
institution National Center for Biotechnology Information
language English
publishDate 1970
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20086082009-09-10 Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A) Bird, C. C. Crawford, Allison M. Currie, A. R. Stirling, B. Fiona Br J Cancer Articles Pretreatment with Metopirone (40 mg.) or SKF 525-A (2 mg./100 g. maternal body weight) protected aganist the embryotoxic and teratogenic actions of7-OHM-12-MBA) (2.5 mg/100 g. maternal body weight) in the Sprague-Dawley rat. At the doses administered SKF-525-A was a more efficient protector than Metopirone. The adrenocorticolytic actions of 7-OHM-12-MBA in the maternal adrenal glands were also prevented by these compounds and a close correlation existed between the degree of protection of the maternal adrenals and of the foetuses. It is suggested that the ultimate embryopathic substance is a metabolite of 7-OHM-12-MBA. IMAGES: Nature Publishing Group 1970-09 /pmc/articles/PMC2008608/ /pubmed/5479302 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Bird, C. C.
Crawford, Allison M.
Currie, A. R.
Stirling, B. Fiona
Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)
title Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)
title_full Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)
title_fullStr Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)
title_full_unstemmed Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)
title_short Protection from the Embryopathic Effects of 7-Hydroxymethyl-12-Methylbenz(a)Anthracene by 2-Methyl-1,2-bis-(3-Pyridyl)-1-Propanone (Metopirone,CIBA) and β-Diethylaminoethyldiphenyl-n-Propyl Acetate (SKF 525-A)
title_sort protection from the embryopathic effects of 7-hydroxymethyl-12-methylbenz(a)anthracene by 2-methyl-1,2-bis-(3-pyridyl)-1-propanone (metopirone,ciba) and β-diethylaminoethyldiphenyl-n-propyl acetate (skf 525-a)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008608/
https://www.ncbi.nlm.nih.gov/pubmed/5479302
work_keys_str_mv AT birdcc protectionfromtheembryopathiceffectsof7hydroxymethyl12methylbenzaanthraceneby2methyl12bis3pyridyl1propanonemetopironecibaandbdiethylaminoethyldiphenylnpropylacetateskf525a
AT crawfordallisonm protectionfromtheembryopathiceffectsof7hydroxymethyl12methylbenzaanthraceneby2methyl12bis3pyridyl1propanonemetopironecibaandbdiethylaminoethyldiphenylnpropylacetateskf525a
AT curriear protectionfromtheembryopathiceffectsof7hydroxymethyl12methylbenzaanthraceneby2methyl12bis3pyridyl1propanonemetopironecibaandbdiethylaminoethyldiphenylnpropylacetateskf525a
AT stirlingbfiona protectionfromtheembryopathiceffectsof7hydroxymethyl12methylbenzaanthraceneby2methyl12bis3pyridyl1propanonemetopironecibaandbdiethylaminoethyldiphenylnpropylacetateskf525a

Ejemplares similares