Further Studies of the Effect of Bone Marrow Cells on Chemically Induced Lymphoma in C57BL/6 Mice

Injection of syngeneic bone marrow cell to adult C57BL/6 mice treated DMBA intragastrically failed to prevent lymphoma induced by the chemical. The present result seem to indicate that bone marrow cells do not hasten the regeneration of the transient injuried thymus by DMBA as compared with their effect in irradiated mice. It appears that, under the conditions used, DMBA does not cause significant damage to the bone marrow since marrow cells from chemically treated mice were as effective as normal marrow cells in: (a) preventing radiogenic leukaemia, (b) repairing radiation damage of the thymus, (c) preventing the lethal action of high doses of irradiation. Marrow cells failed to restore antibody formation to Shigella depressed by DMBA as they do in irradiated mice. The result strengthen our previous view on the critical role of bone marrow on the effects caused by irradiation and not in the leukaemia process as such.