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Immunopathology of Oral Leukoplakia

The lymphocyte transformation test was performed with autologous saline homogenates of leukoplakia. A negative correlation was established (P<0.05) between the (14)C thymidine uptake of lymphocytes in vitro and the non-pyroninophilic mononuclear cell infiltration in biopsies. A depression of lymp...

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Autor principal: Lehner, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008613/
https://www.ncbi.nlm.nih.gov/pubmed/4319938
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author Lehner, T.
author_facet Lehner, T.
author_sort Lehner, T.
collection PubMed
description The lymphocyte transformation test was performed with autologous saline homogenates of leukoplakia. A negative correlation was established (P<0.05) between the (14)C thymidine uptake of lymphocytes in vitro and the non-pyroninophilic mononuclear cell infiltration in biopsies. A depression of lymphocyte transformation was revealed in patients with carcinoma or carcinoma in situ and some with epithelial atypia, as compared with those showing only hyperkeratosis and to a less extent those with acanthosis. A corresponding depression was not found when lymphocytes were stimulated with phytohaemagglutinin, Candida albicans or Herpes simplex antigens. The Pyroninophilic cell count was raised in biopsies with carcinoma or carcinoma in situ and in some with epithelial atypia or acanthosis. These result suggest that in leukoplakia the carcinomatous transformation may be associated with some immunological changes.
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spelling pubmed-20086132009-09-10 Immunopathology of Oral Leukoplakia Lehner, T. Br J Cancer Articles The lymphocyte transformation test was performed with autologous saline homogenates of leukoplakia. A negative correlation was established (P<0.05) between the (14)C thymidine uptake of lymphocytes in vitro and the non-pyroninophilic mononuclear cell infiltration in biopsies. A depression of lymphocyte transformation was revealed in patients with carcinoma or carcinoma in situ and some with epithelial atypia, as compared with those showing only hyperkeratosis and to a less extent those with acanthosis. A corresponding depression was not found when lymphocytes were stimulated with phytohaemagglutinin, Candida albicans or Herpes simplex antigens. The Pyroninophilic cell count was raised in biopsies with carcinoma or carcinoma in situ and in some with epithelial atypia or acanthosis. These result suggest that in leukoplakia the carcinomatous transformation may be associated with some immunological changes. Nature Publishing Group 1970-09 /pmc/articles/PMC2008613/ /pubmed/4319938 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Lehner, T.
Immunopathology of Oral Leukoplakia
title Immunopathology of Oral Leukoplakia
title_full Immunopathology of Oral Leukoplakia
title_fullStr Immunopathology of Oral Leukoplakia
title_full_unstemmed Immunopathology of Oral Leukoplakia
title_short Immunopathology of Oral Leukoplakia
title_sort immunopathology of oral leukoplakia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008613/
https://www.ncbi.nlm.nih.gov/pubmed/4319938
work_keys_str_mv AT lehnert immunopathologyoforalleukoplakia