Intrathecal Chemotherapy: Selection of Cytostatic Agents

Selection of cytostatic agents for intrathecal administration is the subject of this paper. Both the toxic side effects—destruction of blood-brain barrier and change of body weight—and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal admi...

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Autores principales: Hayakawa, T., Yamada, R., Kanai, N., Kuroda, R., Ushio, Y., Higashi, H., Mogami, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008617/
https://www.ncbi.nlm.nih.gov/pubmed/4990920
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author Hayakawa, T.
Yamada, R.
Kanai, N.
Kuroda, R.
Ushio, Y.
Higashi, H.
Mogami, H.
author_facet Hayakawa, T.
Yamada, R.
Kanai, N.
Kuroda, R.
Ushio, Y.
Higashi, H.
Mogami, H.
author_sort Hayakawa, T.
collection PubMed
description Selection of cytostatic agents for intrathecal administration is the subject of this paper. Both the toxic side effects—destruction of blood-brain barrier and change of body weight—and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of various cytostatic agents. As a result, it may be concluded that Methotrexate and Endoxan and lower dose of mitomycin C are suitable drugs for intrathecal chemotherapy. Based on these findings, clinical cases of malignant brain tumours were treated with intrathecal chemotherapy. Grateful acknowledgement is made to Professor Dennosuke Jinnai for his constant interest and guidance in this investigation.
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spelling pubmed-20086172009-09-10 Intrathecal Chemotherapy: Selection of Cytostatic Agents Hayakawa, T. Yamada, R. Kanai, N. Kuroda, R. Ushio, Y. Higashi, H. Mogami, H. Br J Cancer Articles Selection of cytostatic agents for intrathecal administration is the subject of this paper. Both the toxic side effects—destruction of blood-brain barrier and change of body weight—and the cytostatic effects on intracranially transplanted Yoshida ascites sarcoma were investigated of intrathecal administration of various cytostatic agents. As a result, it may be concluded that Methotrexate and Endoxan and lower dose of mitomycin C are suitable drugs for intrathecal chemotherapy. Based on these findings, clinical cases of malignant brain tumours were treated with intrathecal chemotherapy. Grateful acknowledgement is made to Professor Dennosuke Jinnai for his constant interest and guidance in this investigation. Nature Publishing Group 1970-09 /pmc/articles/PMC2008617/ /pubmed/4990920 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Hayakawa, T.
Yamada, R.
Kanai, N.
Kuroda, R.
Ushio, Y.
Higashi, H.
Mogami, H.
Intrathecal Chemotherapy: Selection of Cytostatic Agents
title Intrathecal Chemotherapy: Selection of Cytostatic Agents
title_full Intrathecal Chemotherapy: Selection of Cytostatic Agents
title_fullStr Intrathecal Chemotherapy: Selection of Cytostatic Agents
title_full_unstemmed Intrathecal Chemotherapy: Selection of Cytostatic Agents
title_short Intrathecal Chemotherapy: Selection of Cytostatic Agents
title_sort intrathecal chemotherapy: selection of cytostatic agents
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008617/
https://www.ncbi.nlm.nih.gov/pubmed/4990920
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AT ushioy intrathecalchemotherapyselectionofcytostaticagents
AT higashih intrathecalchemotherapyselectionofcytostaticagents
AT mogamih intrathecalchemotherapyselectionofcytostaticagents

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