Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid

1. Mice have been compeletly protected against the lethal effects of repeated injections of methotrexate by 5-methyltetrahydrofolic acid. Methotrexate-resistant cells probably owe their resistance to their high content of this substance. 2. Daily small doses were much more effective than fewer but l...

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Detalles Bibliográficos
Autores principales: Blair, J. A., Searle, C. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008620/
https://www.ncbi.nlm.nih.gov/pubmed/5312191
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author Blair, J. A.
Searle, C. E.
author_facet Blair, J. A.
Searle, C. E.
author_sort Blair, J. A.
collection PubMed
description 1. Mice have been compeletly protected against the lethal effects of repeated injections of methotrexate by 5-methyltetrahydrofolic acid. Methotrexate-resistant cells probably owe their resistance to their high content of this substance. 2. Daily small doses were much more effective than fewer but larger doses. 3. The reduced efficiency found in counteracting high dosages of methotrexate may be due to interference with folate transport across cell walls. 4. 5-Methyltetrahydrofolic acid and citrovorum factor did not differ greatly in their ability to inhibit methotre toxicity. It is suggested that the pharmaceutical effects of citrovorum factor are due to its conversion to 5-methyltetrahydrofolic acid.
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spelling pubmed-20086202009-09-10 Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid Blair, J. A. Searle, C. E. Br J Cancer Articles 1. Mice have been compeletly protected against the lethal effects of repeated injections of methotrexate by 5-methyltetrahydrofolic acid. Methotrexate-resistant cells probably owe their resistance to their high content of this substance. 2. Daily small doses were much more effective than fewer but larger doses. 3. The reduced efficiency found in counteracting high dosages of methotrexate may be due to interference with folate transport across cell walls. 4. 5-Methyltetrahydrofolic acid and citrovorum factor did not differ greatly in their ability to inhibit methotre toxicity. It is suggested that the pharmaceutical effects of citrovorum factor are due to its conversion to 5-methyltetrahydrofolic acid. Nature Publishing Group 1970-09 /pmc/articles/PMC2008620/ /pubmed/5312191 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Blair, J. A.
Searle, C. E.
Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
title Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
title_full Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
title_fullStr Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
title_full_unstemmed Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
title_short Reversal of Methotrexate Toxicity in Mice by 5-Methyltetrahydrofolic Acid
title_sort reversal of methotrexate toxicity in mice by 5-methyltetrahydrofolic acid
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008620/
https://www.ncbi.nlm.nih.gov/pubmed/5312191
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AT searlece reversalofmethotrexatetoxicityinmiceby5methyltetrahydrofolicacid

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