Cargando…

The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*

In tobacco carcinogenesis research, considerable attention has been paid to the choice of the bioassay. The ideal system should simulate the human smoking setting as closely as possible and should utilize tissue of a type similar to that found at the sites where the tobacco smoke-related cancers ori...

Descripción completa

Detalles Bibliográficos
Autores principales: Wynder, E. L., Hoffmann, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008622/
https://www.ncbi.nlm.nih.gov/pubmed/4920216
_version_ 1782135953707499520
author Wynder, E. L.
Hoffmann, D.
author_facet Wynder, E. L.
Hoffmann, D.
author_sort Wynder, E. L.
collection PubMed
description In tobacco carcinogenesis research, considerable attention has been paid to the choice of the bioassay. The ideal system should simulate the human smoking setting as closely as possible and should utilize tissue of a type similar to that found at the sites where the tobacco smoke-related cancers originate in man. However, although certain inhalation experiments in the laboratory meet these requirements to some extent, they are generally timeconsuming and difficult to evaluate and since they usually have to be performed on large animals, are extremely costly when used for the identification of the actual tumorigenic agents in the smoke. The present article examines the reasons why mouse skin is a useful bioassay. The system has enabled investigators to identify tumour initiators and accelerators and to determine that the major tumour promoters reside in the weakly acidic portion of tobacco smoke. The mouse skin bioassay demonstrated that with significant inhibition of the pyrosynthesis of alkylated and non-alkylated polynuclear aromatic hydrocarbons, the tumorigenicity of the “tar” will also decrease significantly. IMAGES:
format Text
id pubmed-2008622
institution National Center for Biotechnology Information
language English
publishDate 1970
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20086222009-09-10 The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* Wynder, E. L. Hoffmann, D. Br J Cancer Articles In tobacco carcinogenesis research, considerable attention has been paid to the choice of the bioassay. The ideal system should simulate the human smoking setting as closely as possible and should utilize tissue of a type similar to that found at the sites where the tobacco smoke-related cancers originate in man. However, although certain inhalation experiments in the laboratory meet these requirements to some extent, they are generally timeconsuming and difficult to evaluate and since they usually have to be performed on large animals, are extremely costly when used for the identification of the actual tumorigenic agents in the smoke. The present article examines the reasons why mouse skin is a useful bioassay. The system has enabled investigators to identify tumour initiators and accelerators and to determine that the major tumour promoters reside in the weakly acidic portion of tobacco smoke. The mouse skin bioassay demonstrated that with significant inhibition of the pyrosynthesis of alkylated and non-alkylated polynuclear aromatic hydrocarbons, the tumorigenicity of the “tar” will also decrease significantly. IMAGES: Nature Publishing Group 1970-09 /pmc/articles/PMC2008622/ /pubmed/4920216 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Wynder, E. L.
Hoffmann, D.
The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
title The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
title_full The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
title_fullStr The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
title_full_unstemmed The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
title_short The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
title_sort epidermis and the respiratory tract as bioassay systems in tobacco carcinogenesis*
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008622/
https://www.ncbi.nlm.nih.gov/pubmed/4920216
work_keys_str_mv AT wynderel theepidermisandtherespiratorytractasbioassaysystemsintobaccocarcinogenesis
AT hoffmannd theepidermisandtherespiratorytractasbioassaysystemsintobaccocarcinogenesis
AT wynderel epidermisandtherespiratorytractasbioassaysystemsintobaccocarcinogenesis
AT hoffmannd epidermisandtherespiratorytractasbioassaysystemsintobaccocarcinogenesis