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The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis*
In tobacco carcinogenesis research, considerable attention has been paid to the choice of the bioassay. The ideal system should simulate the human smoking setting as closely as possible and should utilize tissue of a type similar to that found at the sites where the tobacco smoke-related cancers ori...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1970
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008622/ https://www.ncbi.nlm.nih.gov/pubmed/4920216 |
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author | Wynder, E. L. Hoffmann, D. |
author_facet | Wynder, E. L. Hoffmann, D. |
author_sort | Wynder, E. L. |
collection | PubMed |
description | In tobacco carcinogenesis research, considerable attention has been paid to the choice of the bioassay. The ideal system should simulate the human smoking setting as closely as possible and should utilize tissue of a type similar to that found at the sites where the tobacco smoke-related cancers originate in man. However, although certain inhalation experiments in the laboratory meet these requirements to some extent, they are generally timeconsuming and difficult to evaluate and since they usually have to be performed on large animals, are extremely costly when used for the identification of the actual tumorigenic agents in the smoke. The present article examines the reasons why mouse skin is a useful bioassay. The system has enabled investigators to identify tumour initiators and accelerators and to determine that the major tumour promoters reside in the weakly acidic portion of tobacco smoke. The mouse skin bioassay demonstrated that with significant inhibition of the pyrosynthesis of alkylated and non-alkylated polynuclear aromatic hydrocarbons, the tumorigenicity of the “tar” will also decrease significantly. IMAGES: |
format | Text |
id | pubmed-2008622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1970 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20086222009-09-10 The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* Wynder, E. L. Hoffmann, D. Br J Cancer Articles In tobacco carcinogenesis research, considerable attention has been paid to the choice of the bioassay. The ideal system should simulate the human smoking setting as closely as possible and should utilize tissue of a type similar to that found at the sites where the tobacco smoke-related cancers originate in man. However, although certain inhalation experiments in the laboratory meet these requirements to some extent, they are generally timeconsuming and difficult to evaluate and since they usually have to be performed on large animals, are extremely costly when used for the identification of the actual tumorigenic agents in the smoke. The present article examines the reasons why mouse skin is a useful bioassay. The system has enabled investigators to identify tumour initiators and accelerators and to determine that the major tumour promoters reside in the weakly acidic portion of tobacco smoke. The mouse skin bioassay demonstrated that with significant inhibition of the pyrosynthesis of alkylated and non-alkylated polynuclear aromatic hydrocarbons, the tumorigenicity of the “tar” will also decrease significantly. IMAGES: Nature Publishing Group 1970-09 /pmc/articles/PMC2008622/ /pubmed/4920216 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Articles Wynder, E. L. Hoffmann, D. The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* |
title | The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* |
title_full | The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* |
title_fullStr | The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* |
title_full_unstemmed | The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* |
title_short | The Epidermis and the Respiratory Tract as Bioassay Systems in Tobacco Carcinogenesis* |
title_sort | epidermis and the respiratory tract as bioassay systems in tobacco carcinogenesis* |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008622/ https://www.ncbi.nlm.nih.gov/pubmed/4920216 |
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