Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate

The effect of the anabolic steroids nandrolone decanoate and oxymetholone on the peripheral blood haemoglobin, total leucocyte and platelet counts was studied in a controlled trial in which patients received standardized chemotherapy for one form of malignant disease. The results indicate that these...

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Detalles Bibliográficos
Autores principales: Rawbone, R. G., Bagshawe, K. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008626/
https://www.ncbi.nlm.nih.gov/pubmed/4343678
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author Rawbone, R. G.
Bagshawe, K. D.
author_facet Rawbone, R. G.
Bagshawe, K. D.
author_sort Rawbone, R. G.
collection PubMed
description The effect of the anabolic steroids nandrolone decanoate and oxymetholone on the peripheral blood haemoglobin, total leucocyte and platelet counts was studied in a controlled trial in which patients received standardized chemotherapy for one form of malignant disease. The results indicate that these agents have no protective effect on bone marrow suppression during cytotoxic chemotherapy. It was observed that the time interval between the initial nadir total leucocyte count and the return to pre-treatment values in those patients receiving the anabolic steroids was significantly shorter than in the control group.
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spelling pubmed-20086262009-09-10 Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate Rawbone, R. G. Bagshawe, K. D. Br J Cancer Articles The effect of the anabolic steroids nandrolone decanoate and oxymetholone on the peripheral blood haemoglobin, total leucocyte and platelet counts was studied in a controlled trial in which patients received standardized chemotherapy for one form of malignant disease. The results indicate that these agents have no protective effect on bone marrow suppression during cytotoxic chemotherapy. It was observed that the time interval between the initial nadir total leucocyte count and the return to pre-treatment values in those patients receiving the anabolic steroids was significantly shorter than in the control group. Nature Publishing Group 1972-10 /pmc/articles/PMC2008626/ /pubmed/4343678 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Rawbone, R. G.
Bagshawe, K. D.
Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate
title Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate
title_full Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate
title_fullStr Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate
title_full_unstemmed Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate
title_short Anabolic Steroids and Bone Marrow Toxicity During Therapy with Methotrexate
title_sort anabolic steroids and bone marrow toxicity during therapy with methotrexate
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008626/
https://www.ncbi.nlm.nih.gov/pubmed/4343678
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