Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture

Slices of human prostatic adenocarcinoma obtained by transurethral resection were maintained in organ culture for 4 days. Preservation of histological appearance was good with little evidence of necrosis within the viable tissue. Slices of tumour cultured in the presence of testosterone showed a mor...

Descripción completa

Detalles Bibliográficos
Autores principales: McMahon, M. J., Butler, A. V. J., Thomas, G. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008634/
https://www.ncbi.nlm.nih.gov/pubmed/5085678
_version_ 1782135956005978112
author McMahon, M. J.
Butler, A. V. J.
Thomas, G. H.
author_facet McMahon, M. J.
Butler, A. V. J.
Thomas, G. H.
author_sort McMahon, M. J.
collection PubMed
description Slices of human prostatic adenocarcinoma obtained by transurethral resection were maintained in organ culture for 4 days. Preservation of histological appearance was good with little evidence of necrosis within the viable tissue. Slices of tumour cultured in the presence of testosterone showed a morphological change to a more differentiated type of neoplasm whereas explants cultured in the absence of steroid hormone, or with stilboestrol diphosphate, showed no change. In the case of a relatively anaplastic tumour, testosterone produced a significant increase in the number of mitotic figures seen. IMAGES:
format Text
id pubmed-2008634
institution National Center for Biotechnology Information
language English
publishDate 1972
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20086342009-09-10 Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture McMahon, M. J. Butler, A. V. J. Thomas, G. H. Br J Cancer Articles Slices of human prostatic adenocarcinoma obtained by transurethral resection were maintained in organ culture for 4 days. Preservation of histological appearance was good with little evidence of necrosis within the viable tissue. Slices of tumour cultured in the presence of testosterone showed a morphological change to a more differentiated type of neoplasm whereas explants cultured in the absence of steroid hormone, or with stilboestrol diphosphate, showed no change. In the case of a relatively anaplastic tumour, testosterone produced a significant increase in the number of mitotic figures seen. IMAGES: Nature Publishing Group 1972-10 /pmc/articles/PMC2008634/ /pubmed/5085678 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
McMahon, M. J.
Butler, A. V. J.
Thomas, G. H.
Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture
title Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture
title_full Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture
title_fullStr Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture
title_full_unstemmed Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture
title_short Morphological Responses of Prostatic Carcinoma to Testosterone in Organ Culture
title_sort morphological responses of prostatic carcinoma to testosterone in organ culture
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008634/
https://www.ncbi.nlm.nih.gov/pubmed/5085678
work_keys_str_mv AT mcmahonmj morphologicalresponsesofprostaticcarcinomatotestosteroneinorganculture
AT butleravj morphologicalresponsesofprostaticcarcinomatotestosteroneinorganculture
AT thomasgh morphologicalresponsesofprostaticcarcinomatotestosteroneinorganculture

Ejemplares similares