The Carcinogenicity of Two Diazadibenzopyrenes

1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4...

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Detalles Bibliográficos
Autores principales: Zajdela, F., Buu-Hoï, N. P., Jacquignon, P., Dufour, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008646/
https://www.ncbi.nlm.nih.gov/pubmed/5071188
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author Zajdela, F.
Buu-Hoï, N. P.
Jacquignon, P.
Dufour, M.
author_facet Zajdela, F.
Buu-Hoï, N. P.
Jacquignon, P.
Dufour, M.
author_sort Zajdela, F.
collection PubMed
description 1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4,11-diazadibenzo(a,h)pyrene (II) shows a greater activity than I. Another hexacyclic diaza-hydrocarbon, 4,12-diazadibenzo(g,p)chrysene (III), which is devoid of a meso-phenanthrenic region, proved totally inactive.
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spelling pubmed-20086462009-09-10 The Carcinogenicity of Two Diazadibenzopyrenes Zajdela, F. Buu-Hoï, N. P. Jacquignon, P. Dufour, M. Br J Cancer Articles 1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4,11-diazadibenzo(a,h)pyrene (II) shows a greater activity than I. Another hexacyclic diaza-hydrocarbon, 4,12-diazadibenzo(g,p)chrysene (III), which is devoid of a meso-phenanthrenic region, proved totally inactive. Nature Publishing Group 1972-08 /pmc/articles/PMC2008646/ /pubmed/5071188 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Zajdela, F.
Buu-Hoï, N. P.
Jacquignon, P.
Dufour, M.
The Carcinogenicity of Two Diazadibenzopyrenes
title The Carcinogenicity of Two Diazadibenzopyrenes
title_full The Carcinogenicity of Two Diazadibenzopyrenes
title_fullStr The Carcinogenicity of Two Diazadibenzopyrenes
title_full_unstemmed The Carcinogenicity of Two Diazadibenzopyrenes
title_short The Carcinogenicity of Two Diazadibenzopyrenes
title_sort carcinogenicity of two diazadibenzopyrenes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008646/
https://www.ncbi.nlm.nih.gov/pubmed/5071188
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