Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro

A study has been made of the uptake of (63)Ni(2+) from its complexes with serum proteins and with the small molecules from a sterile autolysate of rat muscle by cells of the C57S/IP line of mouse dermal fibroblasts in vitro. Nickel from these complexes is incorporated intracellularly, the distributi...

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Detalles Bibliográficos
Autores principales: Webb, M., Weinzierl, Susan M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008648/
https://www.ncbi.nlm.nih.gov/pubmed/5071191
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author Webb, M.
Weinzierl, Susan M.
author_facet Webb, M.
Weinzierl, Susan M.
author_sort Webb, M.
collection PubMed
description A study has been made of the uptake of (63)Ni(2+) from its complexes with serum proteins and with the small molecules from a sterile autolysate of rat muscle by cells of the C57S/IP line of mouse dermal fibroblasts in vitro. Nickel from these complexes is incorporated intracellularly, the distribution being independent of the nature of the carrier. The cation is associated with all subcellular fractions, the largest amount being bound by the nuclei and the least by the microsomes. About half of the (63)Ni(2+) incorporated into the nuclei is located in the nucleoli.
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spelling pubmed-20086482009-09-10 Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro Webb, M. Weinzierl, Susan M. Br J Cancer Articles A study has been made of the uptake of (63)Ni(2+) from its complexes with serum proteins and with the small molecules from a sterile autolysate of rat muscle by cells of the C57S/IP line of mouse dermal fibroblasts in vitro. Nickel from these complexes is incorporated intracellularly, the distribution being independent of the nature of the carrier. The cation is associated with all subcellular fractions, the largest amount being bound by the nuclei and the least by the microsomes. About half of the (63)Ni(2+) incorporated into the nuclei is located in the nucleoli. Nature Publishing Group 1972-08 /pmc/articles/PMC2008648/ /pubmed/5071191 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Webb, M.
Weinzierl, Susan M.
Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro
title Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro
title_full Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro
title_fullStr Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro
title_full_unstemmed Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro
title_short Uptake of (63)Ni(2+) from its Complexes with Proteins and other Ligands by Mouse Dermal Fibroblasts in vitro
title_sort uptake of (63)ni(2+) from its complexes with proteins and other ligands by mouse dermal fibroblasts in vitro
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008648/
https://www.ncbi.nlm.nih.gov/pubmed/5071191
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