The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma

The gross response of a transplantable fibrosarcoma (RIB(5)) in rats treated with a single dose of 10, 50, 100 or 200 mg/kg body weight of cyclophosphamide (CP) is reported. The variation in mitotic and tritiated thymidine ((3)H-TdR) labelling indices after a single dose of 100 mg/kg CP was studied....

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Detalles Bibliográficos
Autores principales: Peel, Sandra, Cowen, Diana M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008649/
https://www.ncbi.nlm.nih.gov/pubmed/5071192
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author Peel, Sandra
Cowen, Diana M.
author_facet Peel, Sandra
Cowen, Diana M.
author_sort Peel, Sandra
collection PubMed
description The gross response of a transplantable fibrosarcoma (RIB(5)) in rats treated with a single dose of 10, 50, 100 or 200 mg/kg body weight of cyclophosphamide (CP) is reported. The variation in mitotic and tritiated thymidine ((3)H-TdR) labelling indices after a single dose of 100 mg/kg CP was studied. Examination of chromosome spreads has shown the time course of the visible damage to DNA caused by CP and a transient arrest of cells in G(2) was demonstrated by microdensitometry. The effects of 100 mg/kg body weight CP given in 2 equal doses separated by various time intervals were examined in an attempt to relate tumour response to its altered cellular state at the time of the second dose.
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spelling pubmed-20086492009-09-10 The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma Peel, Sandra Cowen, Diana M. Br J Cancer Articles The gross response of a transplantable fibrosarcoma (RIB(5)) in rats treated with a single dose of 10, 50, 100 or 200 mg/kg body weight of cyclophosphamide (CP) is reported. The variation in mitotic and tritiated thymidine ((3)H-TdR) labelling indices after a single dose of 100 mg/kg CP was studied. Examination of chromosome spreads has shown the time course of the visible damage to DNA caused by CP and a transient arrest of cells in G(2) was demonstrated by microdensitometry. The effects of 100 mg/kg body weight CP given in 2 equal doses separated by various time intervals were examined in an attempt to relate tumour response to its altered cellular state at the time of the second dose. Nature Publishing Group 1972-08 /pmc/articles/PMC2008649/ /pubmed/5071192 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Peel, Sandra
Cowen, Diana M.
The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma
title The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma
title_full The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma
title_fullStr The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma
title_full_unstemmed The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma
title_short The Effect of Cyclophosphamide on the Growth and Cellular Kinetics of a Transplantable Rat Fibrosarcoma
title_sort effect of cyclophosphamide on the growth and cellular kinetics of a transplantable rat fibrosarcoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008649/
https://www.ncbi.nlm.nih.gov/pubmed/5071192
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