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Oestrogen Metabolism in Cultured Human Breast Tumours
The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in th...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1972
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008668/ https://www.ncbi.nlm.nih.gov/pubmed/4345953 |
| Sumario: | The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in the ratios of oestradiol-17β/oestrone achieved. The fact that malignant tumours were able to convert oestrone to oestradiol-17β is of interest in view of the relatively high plasma levels of oestrone in post-menopausal women. IMAGES: |
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