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Oestrogen Metabolism in Cultured Human Breast Tumours

The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in th...

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Detalles Bibliográficos
Autores principales: Willcox, P. A., Thomas, G. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008668/
https://www.ncbi.nlm.nih.gov/pubmed/4345953
Descripción
Sumario:The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in the ratios of oestradiol-17β/oestrone achieved. The fact that malignant tumours were able to convert oestrone to oestradiol-17β is of interest in view of the relatively high plasma levels of oestrone in post-menopausal women. IMAGES: