Oestrogen Metabolism in Cultured Human Breast Tumours

The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in th...

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Detalles Bibliográficos
Autores principales: Willcox, P. A., Thomas, G. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1972
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008668/
https://www.ncbi.nlm.nih.gov/pubmed/4345953
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author Willcox, P. A.
Thomas, G. H.
author_facet Willcox, P. A.
Thomas, G. H.
author_sort Willcox, P. A.
collection PubMed
description The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in the ratios of oestradiol-17β/oestrone achieved. The fact that malignant tumours were able to convert oestrone to oestradiol-17β is of interest in view of the relatively high plasma levels of oestrone in post-menopausal women. IMAGES:
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spelling pubmed-20086682009-09-10 Oestrogen Metabolism in Cultured Human Breast Tumours Willcox, P. A. Thomas, G. H. Br J Cancer Articles The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in the ratios of oestradiol-17β/oestrone achieved. The fact that malignant tumours were able to convert oestrone to oestradiol-17β is of interest in view of the relatively high plasma levels of oestrone in post-menopausal women. IMAGES: Nature Publishing Group 1972-12 /pmc/articles/PMC2008668/ /pubmed/4345953 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Willcox, P. A.
Thomas, G. H.
Oestrogen Metabolism in Cultured Human Breast Tumours
title Oestrogen Metabolism in Cultured Human Breast Tumours
title_full Oestrogen Metabolism in Cultured Human Breast Tumours
title_fullStr Oestrogen Metabolism in Cultured Human Breast Tumours
title_full_unstemmed Oestrogen Metabolism in Cultured Human Breast Tumours
title_short Oestrogen Metabolism in Cultured Human Breast Tumours
title_sort oestrogen metabolism in cultured human breast tumours
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008668/
https://www.ncbi.nlm.nih.gov/pubmed/4345953
work_keys_str_mv AT willcoxpa oestrogenmetabolisminculturedhumanbreasttumours
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