The Effect of the Age of Mice on the Incidence of Skin Cancer

The plausibilities of two hypotheses explaining the increased cancer incidence rate in old age caused by a constant dose of carcinogen were compared using a mouse skin painting experiment in which two groups of mice started treatment at different ages. It was shown that the hypothesis of the increas...

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Detalles Bibliográficos
Autores principales: Lee, P. N., Peto, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1970
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008705/
https://www.ncbi.nlm.nih.gov/pubmed/5503606
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author Lee, P. N.
Peto, R.
author_facet Lee, P. N.
Peto, R.
author_sort Lee, P. N.
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description The plausibilities of two hypotheses explaining the increased cancer incidence rate in old age caused by a constant dose of carcinogen were compared using a mouse skin painting experiment in which two groups of mice started treatment at different ages. It was shown that the hypothesis of the increased rate being caused simply by increased vulnerability of old animals was not as plausible as the alternative hypothesis of the carcinogen acting to some extent cumulatively.
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spelling pubmed-20087052009-09-10 The Effect of the Age of Mice on the Incidence of Skin Cancer Lee, P. N. Peto, R. Br J Cancer Articles The plausibilities of two hypotheses explaining the increased cancer incidence rate in old age caused by a constant dose of carcinogen were compared using a mouse skin painting experiment in which two groups of mice started treatment at different ages. It was shown that the hypothesis of the increased rate being caused simply by increased vulnerability of old animals was not as plausible as the alternative hypothesis of the carcinogen acting to some extent cumulatively. Nature Publishing Group 1970-12 /pmc/articles/PMC2008705/ /pubmed/5503606 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Lee, P. N.
Peto, R.
The Effect of the Age of Mice on the Incidence of Skin Cancer
title The Effect of the Age of Mice on the Incidence of Skin Cancer
title_full The Effect of the Age of Mice on the Incidence of Skin Cancer
title_fullStr The Effect of the Age of Mice on the Incidence of Skin Cancer
title_full_unstemmed The Effect of the Age of Mice on the Incidence of Skin Cancer
title_short The Effect of the Age of Mice on the Incidence of Skin Cancer
title_sort effect of the age of mice on the incidence of skin cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008705/
https://www.ncbi.nlm.nih.gov/pubmed/5503606
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