The Primary Implantation of Human Tumours to the Hamster Cheek Pouch

The hamster cheek pouch is an immunologically privileged site. The present study is of simple implantation of human tumours direct from operative specimen to cheek pouch, in particular to determine whether tumour type influences the rate of successful implant. All implants were studied 10 or 20 days...

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Detalles Bibliográficos
Autores principales: Williams, Dorothy E., Evans, D. M. D., Blamey, R. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1971
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008741/
https://www.ncbi.nlm.nih.gov/pubmed/5144526
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author Williams, Dorothy E.
Evans, D. M. D.
Blamey, R. W.
author_facet Williams, Dorothy E.
Evans, D. M. D.
Blamey, R. W.
author_sort Williams, Dorothy E.
collection PubMed
description The hamster cheek pouch is an immunologically privileged site. The present study is of simple implantation of human tumours direct from operative specimen to cheek pouch, in particular to determine whether tumour type influences the rate of successful implant. All implants were studied 10 or 20 days later. The use of cortisone significantly improved the number of implants growing. Carcinomas of the cervix were found to show growth in 55% of implants, in animals conditioned with cortisone. Growth from tumours of the uterine body, or from colorectal carcinomas, occurred in 25-30% of implants. Breast cancer gave poor results. IMAGES:
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spelling pubmed-20087412009-09-10 The Primary Implantation of Human Tumours to the Hamster Cheek Pouch Williams, Dorothy E. Evans, D. M. D. Blamey, R. W. Br J Cancer Articles The hamster cheek pouch is an immunologically privileged site. The present study is of simple implantation of human tumours direct from operative specimen to cheek pouch, in particular to determine whether tumour type influences the rate of successful implant. All implants were studied 10 or 20 days later. The use of cortisone significantly improved the number of implants growing. Carcinomas of the cervix were found to show growth in 55% of implants, in animals conditioned with cortisone. Growth from tumours of the uterine body, or from colorectal carcinomas, occurred in 25-30% of implants. Breast cancer gave poor results. IMAGES: Nature Publishing Group 1971-09 /pmc/articles/PMC2008741/ /pubmed/5144526 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Williams, Dorothy E.
Evans, D. M. D.
Blamey, R. W.
The Primary Implantation of Human Tumours to the Hamster Cheek Pouch
title The Primary Implantation of Human Tumours to the Hamster Cheek Pouch
title_full The Primary Implantation of Human Tumours to the Hamster Cheek Pouch
title_fullStr The Primary Implantation of Human Tumours to the Hamster Cheek Pouch
title_full_unstemmed The Primary Implantation of Human Tumours to the Hamster Cheek Pouch
title_short The Primary Implantation of Human Tumours to the Hamster Cheek Pouch
title_sort primary implantation of human tumours to the hamster cheek pouch
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008741/
https://www.ncbi.nlm.nih.gov/pubmed/5144526
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